{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T18:25:04Z","timestamp":1748715904057,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,20]],"date-time":"2018-05-20T00:00:00Z","timestamp":1526774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The pathogenesis of juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) remains unknown, but imbalance between the oxidant and antioxidant defense systems may play a role. Measuring thiols in plasma provides an indirect indication of antioxidative defense. The aim of the present study was to investigate the association between <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and dynamic thiol\/disulfide homeostatic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study involved 34 <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> patients and 30 age\u2010 and gender\u2010matched healthy controls. The\u00a0patients were divided into subgroups according to Simplified Disease Activity Index (<jats:styled-content style=\"fixed-case\">SDAI<\/jats:styled-content>) score: active, <jats:styled-content style=\"fixed-case\">SDAI<\/jats:styled-content> &gt; 3.3; remission, <jats:styled-content style=\"fixed-case\">SDAI<\/jats:styled-content> \u2264 3.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Native thiol and total thiol were significantly lower in the <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> group than in the control group (<jats:italic>P<\/jats:italic> = 0.001). There was no significant difference in the disulfide\/native thiol, disulfide\/total thiol, and native thiol\/total thiol ratios between the <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and control groups (<jats:italic>P<\/jats:italic> &gt; 0.05). Based on <jats:styled-content style=\"fixed-case\">SDAI<\/jats:styled-content> score, 22 <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> patients were in the remission subgroup, and 12 <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> patients were in the active subgroup. Native thiol and total thiol were significantly lower in the active <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> subgroup than in the remission subgroup (<jats:italic>P<\/jats:italic> = 0.001), but there were no significant differences in the other parameters. There was no significant difference in thiol and disulfide levels between systemic\u2010onset <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and other <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma thiol is lower in <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> patients, especially during periods of active disease, than in healthy controls, indicating that low thiol might be an important factor in the etiology of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and that antioxidant systems are negatively affected by inflammatory diseases, especially during periods of active disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13569","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T06:48:04Z","timestamp":1521787684000},"page":"593-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in thiol\/disulfide homeostasis in juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0333-6979","authenticated-orcid":false,"given":"Esma","family":"Altinel Acoglu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozcan","family":"Erel","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Yildirim Beyazit University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Yazilitas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Bulbul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melahat Melek","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husniye","family":"Yucel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can Demir","family":"Karacan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency Medicine Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saliha","family":"Senel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"205","article-title":"Juvenile idiopathic arthritis","volume":"65","author":"Haines KA","year":"2007","journal-title":"Bull. 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