{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:42:22Z","timestamp":1767166942217,"version":"build-2238731810"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to assess the diagnostic value of urinary fibrin\/fibrinogen degradation products (\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      ) measured using an anti\u2010fibrinogen antibody in patients with orthostatic proteinuria (\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      ), and their use in differentiating between\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      and glomerulonephritis (\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      were measured using first urine in the morning (supine) and non\u2010first urine during a hospital visit (upright) and then normalized to urine creatinine (\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      \/Cr, ng\/mgCr). We compared (i)\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 16); (ii)\u00a0those in remission from nephrotic syndrome (\n                      <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                      ,\n                      <jats:italic>n<\/jats:italic>\n                      = 14) and from\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      (IgA nephropathy [Ig\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      ],\n                      <jats:italic>n<\/jats:italic>\n                      = 14; Henoch\u2013Sch\u00f6nlein purpura nephritis [\n                      <jats:styled-content style=\"fixed-case\">HSPN<\/jats:styled-content>\n                      ],\n                      <jats:italic>n<\/jats:italic>\n                      = 12); and (iii) those with active\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      (Ig\n                      <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>\n                      ,\n                      <jats:italic>n<\/jats:italic>\n                      = 12;\n                      <jats:styled-content style=\"fixed-case\">HSPN<\/jats:styled-content>\n                      ,\n                      <jats:italic>n<\/jats:italic>\n                      = 19).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      \/Cr ratio increased from supine to upright urine in patients with\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), but decreased in one case.\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      were excreted in supine urine in 94% of\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      patients, with no excretion in\n                      <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                      remission patients or in 92% of\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      remission patients (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001 for both).\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      \/Cr in supine urine was similar between the\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      and active\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      patients (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.40), whereas proteinuria in supine urine was in the normal range in all\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      patients, but was significantly higher in upright urine in the\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      patients (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). In upright urine, urinary protein\/creatinine ratio was significantly lower in patients with\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      than in those with active\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005). A\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      \/Cr ratio cut\u2010off of 1,108\u00a0ng\/mgCr in upright urine correctly differentiated\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      from active\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      , with a sensitivity of 87.5% and a specificity of 100%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Comparison of\n                      <jats:styled-content style=\"fixed-case\">uFDP<\/jats:styled-content>\n                      levels in supine\/upright urine can be reliable for diagnosing\n                      <jats:styled-content style=\"fixed-case\">OP<\/jats:styled-content>\n                      and for differentiating it from active\n                      <jats:styled-content style=\"fixed-case\">GN<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.13576","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T01:19:36Z","timestamp":1523668776000},"page":"639-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urinary fibrin\/fibrinogen degradation products measured using an anti\u2010fibrinogen antibody predict orthostatic proteinuria"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-237X","authenticated-orcid":false,"given":"Hiroaki","family":"Kanai","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Sawanobori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Higashida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2519","volume-title":"Nelson Textbook of Pediatrics","author":"Porter CC","year":"2015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1451-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.6.1242"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922810380904"},{"key":"e_1_2_8_6_1","first-page":"1060","article-title":"Exercise proteinuria and hematuria: Current knowledge and future directions","volume":"56","author":"Shephard RJ","year":"2016","journal-title":"J. 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