{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:22:02Z","timestamp":1790788922003,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute post\u2010streptococcal glomerulonephritis (<jats:styled-content style=\"fixed-case\">APSGN<\/jats:styled-content>) is the most common post\u2010infectious glomerulonephritis in childhood. The aim of this study was therefore to identify the possible risk factor(s) responsible for decreased glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">APSGN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of patients followed up with a diagnosis of <jats:styled-content style=\"fixed-case\">APSGN<\/jats:styled-content> in the Pediatric Nephrology Clinic of Gaziantep University Hospital between October 2014 and October 2016 were retrospectively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total number of subjects was 75 (male\/female, 42\/33) with a mean age of 8.20 \u00b1 3.25 years. The most common presentations were edema (86.7%), macroscopic hematuria (82.7%) and hypertension (73.3%, <jats:italic>n<\/jats:italic> = 55). On laboratory examination, 28 children (37.3%) had hypoalbuminemia, 58 (77.3%) had proteinuria, 20 (26.7%) had increased C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), while 74 (98.7%) and 12 (16%) had decreased complement (C)3 and C4, respectively. The number of children with <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> &lt;90 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73 m<jats:sup>2<\/jats:sup> was 22 (29.3%). The risk of decreased <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> was significantly higher in patients with increased <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.001; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 3.58), hypoalbuminemia (<jats:italic>P<\/jats:italic> = 0.006; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 4.83), and decreased C4 (<jats:italic>P<\/jats:italic> = 0.010; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 11.53). Additionally, white blood cell (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) count, neutrophil count, and neutrophil\/lymphocyte ratio (<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) were significantly higher (<jats:italic>P<\/jats:italic> = 0.02, <jats:italic>P<\/jats:italic> = 0.006, <jats:italic>P<\/jats:italic> = 0.004, respectively) in patients with low <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the prognosis of <jats:styled-content style=\"fixed-case\">APSGN<\/jats:styled-content> in children is good, severe systemic complications and renal failure may develop during the follow\u2010up period. Decreased C4, presence of hypoalbuminemia, and increased inflammatory markers (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CRP<\/jats:styled-content>, neutrophil count and <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) might be possible risk factors for severity of renal involvement. Decreased C4, in particular, may be a risk factor for decreased <jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> in those children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13587","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T09:04:09Z","timestamp":1525511049000},"page":"645-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Pediatric post\u2010streptococcal glomerulonephritis: Clinical and laboratory data"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-2139","authenticated-orcid":false,"given":"Beltinge","family":"Demircioglu K\u0131l\u0131c","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology Faculty of Medicine Gaziantep University Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehtap","family":"Akbal\u0131k Kara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Faculty of Medicine Gaziantep University Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithat","family":"Buyukcelik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Faculty of Medicine Gaziantep University Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Balat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Faculty of Medicine Istanbul Ayd\u0131n University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-43596-0_27"},{"key":"e_1_2_8_3_1","first-page":"151","article-title":"Myocardial functions of children with acute poststreptococcal glomerulonephritis","volume":"39","author":"Balat A","year":"1993","journal-title":"Clin. 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