{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:35:07Z","timestamp":1788305707345,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the clinical features of patients with multicystic dysplastic kidney (<jats:styled-content style=\"fixed-case\">MCDK<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical files of children diagnosed with <jats:styled-content style=\"fixed-case\">MCDK<\/jats:styled-content> between January 2008 and November 2015 were retrospectively reviewed. The demographic, clinical, laboratory and radiological data were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 128 children with <jats:styled-content style=\"fixed-case\">MCDK<\/jats:styled-content> enrolled in the study, 82 (64.1%) were male, and 46 (35.9%) were female (<jats:italic>P<\/jats:italic>\u00a0&lt; 0.05). <jats:styled-content style=\"fixed-case\">MCDK<\/jats:styled-content> were located on left and right sides in 66 (51.6%) and 62 children (48.4%), respectively (<jats:italic>P<\/jats:italic> &gt; 0.05). Antenatal diagnosis was present in 64 patients (50%). The mean age at diagnosis was 2.8 \u00b1 2.7\u00a0years (range, 0\u20138\u00a0years), and follow\u2010up duration was 4.5\u00a0years. Fifteen patients (20.8%) had vesicoureteral reflux. Of these, four underwent endoscopic surgical correction. Other associated urological anomalies were ureteropelvic junction obstruction (<jats:italic>n<\/jats:italic> = 6), hypospadias (<jats:italic>n<\/jats:italic> = 1), and kidney stones (<jats:italic>n<\/jats:italic> = 1). On technetium\u201099\u00a0<jats:italic>m<\/jats:italic> dimercaptosuccinic acid scintigraphy, which was performed in all patients, no significant association between grade of reflux and presence of scarring was seen. Hypertension was diagnosed only in one child (0.8%) who required antihypertensive treatment. The prevalence of unilateral undescended testicle in children aged &lt;1\u00a0year in the 82 male patients was 4.9%. Seventy\u2010six patients (59.4%) developed compensatory hypertrophy in the contralateral kidney during a 1\u00a0year follow\u2010up period. Of the total, only seven children (5.5%) had undergone nephrectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MCDK<\/jats:styled-content> follows a benign course with relatively few sequelae, and therefore these patients should be closely followed up and conservatively managed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13612","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T13:19:10Z","timestamp":1527859150000},"page":"750-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical features of children with multicystic dysplastic kidney"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-0444","authenticated-orcid":false,"given":"Aslihan","family":"Kara","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology Firat University School of Medicine Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin Kaya","family":"Gurgoze","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Firat University School of Medicine Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Neonatology Firat University School of Medicine Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra Pinar","family":"Koc","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Firat University School of Medicine Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.01.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn777"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-009-0117-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0746-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-015-0541-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02019071"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)81825-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000138818.10910.1f"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.075333"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2012.04.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388714"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01640309"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832f4f6b"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2014.03.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289503400106"},{"key":"e_1_2_7_18_1","unstructured":"Swiatecka\u2010UrbanA.Multicystic renal dysplasia. 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