{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:57Z","timestamp":1772160897008,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Stevens\u2013Johnson syndrome (\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      ) and toxic epidermal necrolysis (\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      ) are rare, but these conditions are associated with high mortality. There have been few reports of\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      in children. The aim of this study was to evaluate the clinical features and outcomes of\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      in a group of Japanese children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed pediatric cases of\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      , from 2000 to 2015.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 12 pediatric cases of\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      and three of\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      . Six (all\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      ) were caused by infection, and eight of the cases (\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      ,\n                      <jats:italic>n<\/jats:italic>\n                      = 5;\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      ,\n                      <jats:italic>n<\/jats:italic>\n                      = 3) were drug induced. Respiratory complications were the most common in terms of organ involvement, followed by hepatitis and gastrointestinal symptoms. Thirteen patients were treated with systemic corticosteroids, and two patients were treated with supportive therapy only. Concomitant with corticosteroid, four patients were given i.v. immunoglobulin. One patient with severe\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      was treated with systemic corticosteroids combined with plasmapheresis and cyclosporine. None of the present patients died. One patient with\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      had severe sequelae, with bronchiolitis obliterans and ocular involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      are rare, but are associated with severe complications. General pediatricians need to have up\u2010to\u2010date information regarding these conditions. The present study provides insights into the confirmation of the risk of\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      as well as the treatment of these diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.13613","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T02:55:35Z","timestamp":1528685735000},"page":"697-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical features of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0459-4128","authenticated-orcid":false,"given":"Satoshi","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Immunology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoka","family":"Kanbe","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenshiro","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Division of Dermatology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Uejima","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Suganuma","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadamasa","family":"Takano","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kawano","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology Saitama Children's Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_7_3_1","first-page":"11","article-title":"Incidence of Stevens\u2010Johnson syndrome and toxic epidermal necrolysis: A nationwide population\u2010based study using National Health Insurance database in Korea","volume":"11","author":"Yang MS","year":"2016","journal-title":"PLoS ONE"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.024"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12388434"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.09.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.085"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225130-00006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.11-OA-0309"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0278"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001476"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2016.16.4.256"},{"key":"e_1_2_7_14_1","first-page":"524","article-title":"Acetaminophen induced Steven Johnson syndrome\u2013toxic epidermal necrolysis overlap","volume":"62","author":"Khawaja A","year":"2012","journal-title":"J. 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