{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:02:36Z","timestamp":1778007756029,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lipid emulsions given i.v. are normally rapidly metabolized by apoprotein recruited from high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) particles in the blood. Very low\u2010birthweight infants (<jats:styled-content style=\"fixed-case\">VLBWI<\/jats:styled-content>), however, have a low rate of lipid clearance from the blood, and therefore lipid emulsions must be given carefully to minimize the risk of hyperlipidemia. The purpose of this study was to evaluate the influence of i.v. lipid emulsion on lipoprotein subclass profile in <jats:styled-content style=\"fixed-case\">VLBWI<\/jats:styled-content> during the early postnatal period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six <jats:styled-content style=\"fixed-case\">VLBWI<\/jats:styled-content> who had been given different doses of lipid emulsion in the first few days after birth were enrolled in the present study. Triglyceride and cholesterol content of each lipoprotein subclass was measured at 3\u00a0weeks after birth, and their correlation with the total dose of lipid emulsion was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no correlation between the total dose of lipid emulsion and the triglyceride and cholesterol content in any subclasses of very low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">VLDL<\/jats:styled-content>) and low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>). There was a significant negative correlation between the total dose of lipid emulsion and the triglyceride content in very large (<jats:italic>P<\/jats:italic> &lt; 0.05, <jats:italic>r<\/jats:italic> = \u22120.32), large (<jats:italic>P<\/jats:italic> &lt; 0.01, <jats:italic>r<\/jats:italic> = \u22120.47) and medium <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.05, <jats:italic>r<\/jats:italic> = \u22120.34) particles; and the cholesterol content in large (<jats:italic>P<\/jats:italic> &lt; 0.01, <jats:italic>r<\/jats:italic> = \u22120.47) and medium <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.01, <jats:italic>r<\/jats:italic> = \u22120.4) particles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lipid emulsion influenced the triglyceride and cholesterol content of <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> particles in <jats:styled-content style=\"fixed-case\">VLBWI<\/jats:styled-content>, suggesting that lipid emulsion can affect lipid metabolism in this infant population in the early postnatal period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13643","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T07:39:44Z","timestamp":1529653184000},"page":"839-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of i.v. lipid emulsion on lipoprotein subclass in preterm infants"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4555-5187","authenticated-orcid":false,"given":"Hiroki","family":"Suganuma","sequence":"first","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine Tokyo 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