{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:53:43Z","timestamp":1773104023159,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurally adjusted ventilatory assist (<jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content>) is expected to improve respiratory outcomes in preterm infants, but it has not yet been evaluated. We investigated whether <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> could improve respiratory outcomes and reduce sedation use in extremely low\u2010birthweight infants (<jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted based on patient charts at the Nagano Children's Hospital neonatal intensive care unit, Japan. Infants who were born at &lt;27 weeks\u2019 gestation were included. We assessed the prevalence of bronchopulmonary dysplasia (<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>), home oxygen therapy (<jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content>), duration of intubation, and sedation use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> group consisted of 14 <jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content> who were born at &lt;27 weeks\u2019 gestation between September 2013 and September 2015. A total of 21 <jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content> born between September 2011 and September 2013, before <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> implementation, served as the control group. There were no significant differences in the perinatal background characteristics between the two groups. For respiratory outcomes, no significant between\u2010group differences were found in the prevalence of <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> or the duration of intubation. The total duration of sedation use was not significantly different between the two groups, but in the <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> group, midazolam was discontinued in all cases after the infants were switched to <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> was safe in preterm infants and had a similar effect to conventional mechanical ventilation with regard to respiratory outcomes and sedation use in the chronic phase; thus, <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> could be used in the early phase, at least before BPD worsens to improve respiratory outcomes in <jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13646","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T20:54:42Z","timestamp":1530046482000},"page":"844-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neurally adjusted ventilatory assist in extremely low\u2010birthweight infants"],"prefix":"10.1111","volume":"60","author":[{"given":"Arata","family":"Oda","sequence":"first","affiliation":[{"name":"Division of Neonatology Nagano Children's Hospital Shinshu University Nagano Japan"},{"name":"Division of Pediatrics and Adolescent Medicine Turku University Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Kamei","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nagano Children's Hospital Shinshu University Nagano 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