{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:26:20Z","timestamp":1773098780272,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary immunodeficiency disorder (<jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>), being a chronic disorder, may increase the prevalence of psychopathologies, but there are few studies on the effect of disease\u2010related factors on psychopathology in this population. The aim of this study was therefore to assess and compare three groups: children with <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> who receive i.v. immunoglobulin treatment; children with juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>); and healthy controls with respect to their mental health status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four children with <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>, 32 children with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and 30 healthy controls, underwent psychiatric evaluation. The Childhood Depression Inventory and the screen for child anxiety\u2010related emotional disorders questionnaire were completed by the participants. The child behavior checklist was completed by the mothers of the participants. In addition, disease\u2010related factors were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of mood disorders between the three groups differed. There was no difference between the <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> groups with respect to the prevalence of mood disorders and other psychopathologies. The disease\u2010related factors were associated with the frequency of mood disorder in <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of psychopathology was similar in patients with <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and higher than the controls. Some of the disease\u2010related factors were associated with the frequency of mood disorders in the <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13675","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T21:16:12Z","timestamp":1534194972000},"page":"911-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Psychological burden of pediatric primary immunodeficiency"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-6288","authenticated-orcid":false,"given":"Binay","family":"Kayan Ocakoglu","sequence":"first","affiliation":[{"name":"Child Psychiatry Outpatient Clinic Batman District State Hospital Batman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan Edeer","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Rheumatology Ege University School of Medicine Bornova, Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fevzi Tuna","family":"Ocakoglu","sequence":"additional","affiliation":[{"name":"Child Psychiatry Outpatient Clinic Batman District State Hospital Batman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Erermis","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Ege University School of Medicine Bornova, Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b13e3181908bf4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/10188-000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1542\/peds.79.5.805","article-title":"Chronic illness, disability, and mental and social well\u2010being: findings of the Ontario Child Health Study","volume":"79","author":"Cadman D","year":"1987","journal-title":"Pediatrics"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4799"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61142-8"},{"key":"e_1_2_8_7_1","first-page":"307","article-title":"Approach to a child with primary immunodeficiency","volume":"37","author":"Han\u0131meli Akta\u015f \u00d6","year":"2010","journal-title":"Dicle T\u0131p Derg."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61263-X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.1.48"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2008.00850.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S58040"},{"key":"e_1_2_8_12_1","first-page":"176","article-title":"Psychiatric aspects of primary immunodeficiency diseases: the parental study","volume":"12","author":"Abolhassani H","year":"2013","journal-title":"Iran. 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