{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:09Z","timestamp":1740126009804,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D, an important factor in calcium\u2010phosphate homeostasis, has recently been suggested to play an important role in the pathogenesis of numerous chronic conditions such as hyperandrogenism. The aim of this study was to investigate the relationship between vitamin D status and premature adrenarche (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 71 girls with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and 52 healthy girls, as the control group, were recruited. Axillary and\/or pubic hair development before the age of 8\u00a0years was defined as <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>. Bone age and anthropometric measures including height, weight, and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) were obtained. 25\u2010Hydroxyvitamin D (25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D), fasting plasma glucose and insulin were measured. Vitamin D insufficiency was defined as &lt;20\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> patients had older bone age, higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> standard deviation score, homeostasis model of assessment\u2013insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>), and androgen but lower 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D than the control group. <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and dehydroepiandrosterone sulfate were also higher in <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> patients with vitamin D insufficiency compared with those with normal vitamin D. There was a negative correlation between 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low vitamin D is associated with <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>; and insulin resistance may be a factor in this association.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13682","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:50:41Z","timestamp":1534953041000},"page":"938-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin D status and premature adrenarche"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-5519","authenticated-orcid":false,"given":"Onur","family":"Ak\u0131n","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysun","family":"Bideci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"D\u00f6\u011fer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Demet Akba\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aylin","family":"Kilin\u00e7 U\u011furlu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman Tolga","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Children's Hospital University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eehri","family":"Elbe\u011f","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhun","family":"\u00c7amurdan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyami","family":"Cinaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"81","article-title":"An experimental investigation on rickets. 1919","volume":"5","author":"Mellanby E","year":"1989","journal-title":"Nutrition"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.05.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04434.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0820342"},{"key":"e_1_2_7_7_1","first-page":"202","article-title":"Does vitamin D status correlate with clinical and biochemical features of polycystic ovary syndrome in high school girls?","volume":"5","author":"Ghadimi R","year":"2014","journal-title":"Caspian J. 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