{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:14:43Z","timestamp":1790709283933,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["IRG5780015"],"award-info":[{"award-number":["IRG5780015"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Type 1 diabetes mellitus (T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) is caused by autoimmune destruction of islet \u03b2\u2010cells of the pancreas. There are overlapping phenotypes in a significant proportion of youth with type 1 and 2 diabetes. Thus, positive pancreatic autoantibodies are helpful to diagnose T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>. Zinc transporter 8 antibody (ZnT8A) is a recently identified autoantibody in T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> and no data on ZnT8A in the Thai population have been reported. The aim of this study was therefore to estimate the prevalence of ZnT8A in Thai juvenile\u2010onset T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> and to evaluate its diagnostic value relative to glutamic acid decarboxylase and insulinoma\u20102 antigen antibodies (<jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>2A).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, patients with T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> diagnosed before age 15\u00a0years, and disease duration &lt;10\u00a0years were enrolled. Serum ZnT8A, <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>2A were measured using commercial enzyme\u2010linked immunosorbent assay kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The subjects consisted of 81 youths (30 boys, 51 girls) aged 12.3 \u00b1 4.5\u00a0years with T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>. The median diabetes duration was 3\u00a0years (range, 0\u201310\u00a0years). The prevalence of ZnT8A, <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>2A was 54.3%, 75.3%, and 45.7%, respectively. ZnT8A were detected in 16% of T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients negative for both <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>2A. A combination of ZnT8A, <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>2A could detect 80.2% of patients with T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>. Combined use of ZnT8A and <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> identified 100% of antibody\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of ZnT8A in Thai juvenile\u2010onset T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> appears to be higher than in previous studies from Asia. ZnT8A could replace <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>2A as an autoimmunity marker in Thai pediatric T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients, with better diagnostic performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13687","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T17:36:01Z","timestamp":1535564161000},"page":"1002-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of islet autoantibodies in Thai juvenile\u2010onset type 1 diabetes"],"prefix":"10.1111","volume":"60","author":[{"given":"Chayanis","family":"Trisorus","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphab","family":"Aroonparkmongkol","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hataichanok Bansiddhi","family":"Kongmanas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-3997","authenticated-orcid":false,"given":"Taninee","family":"Sahakitrungruang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1140"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17477160600586747"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03327467"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2003.16.1.71"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2010.00706.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.12.1755"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5372\/1905-7415.0806.348"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2012.00916.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418375"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.S52"},{"key":"e_1_2_8_13_1","first-page":"1608","article-title":"Etiology and glycemic control among Thai children and adolescents with diabetes mellitus","volume":"90","author":"Santiprabhob J","year":"2007","journal-title":"J. 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