{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:01Z","timestamp":1740126001084,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transient tachypnea of the newborn (<jats:styled-content style=\"fixed-case\">TTN<\/jats:styled-content>) is a respiratory disorder that results from inadequate or delayed clearance of fetal lung fluid following delivery. At present, supportive care is generally practiced for the treatment of <jats:styled-content style=\"fixed-case\">TTN<\/jats:styled-content>. In this study, we focused on inhaled beta\u2010agonists for the treatment of <jats:styled-content style=\"fixed-case\">TTN<\/jats:styled-content>, and the aim was to verify the efficacy and the safety of inhaled procaterol for the treatment of <jats:styled-content style=\"fixed-case\">TTN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inhaled procaterol or normal saline solution was administered to infants. Respiratory rate and mixed venous carbon dioxide (Pv<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub>) were evaluated as the primary outcomes. The duration of hospitalization, duration of oxygen therapy, and changes in respiratory support were evaluated as secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven neonates diagnosed with <jats:styled-content style=\"fixed-case\">TTN<\/jats:styled-content> were randomly assigned to the procaterol group (<jats:italic>n<\/jats:italic> = 18) or the placebo group (<jats:italic>n<\/jats:italic> = 19). There were no differences in Pv<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> or respiratory rate between the two groups before and after intervention. Median duration of oxygen therapy (3 days; <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 3\u20136.5 days vs 2 days, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 2\u20134.75 days; <jats:italic>P<\/jats:italic> = 0.13) and of hospitalization (15 days; <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 11.25\u201320 days vs 11 days, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 8\u201315.5 days; <jats:italic>P<\/jats:italic> = 0.14) were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inhaled procaterol was not effective for the treatment of <jats:styled-content style=\"fixed-case\">TTN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13699","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T05:49:45Z","timestamp":1537768185000},"page":"1014-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhaled procaterol for the treatment of transient tachypnea of the newborn"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-3146","authenticated-orcid":false,"given":"Akinobu","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Neonatology Ogaki Municipal Hospital Ogaki Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal\u2010Neonatal Care Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Matsusawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Okazaki City Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Okazaki City Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80545-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1966.02090070078010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211242"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.507971"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02823875"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb09060.x"},{"key":"e_1_2_8_9_1","first-page":"585","article-title":"Classification of acute respiratory disorders of all newborns in a tertiary care center","volume":"95","author":"Agrawal V","year":"2003","journal-title":"J. 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