{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:01:34Z","timestamp":1788278494644,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T00:00:00Z","timestamp":1545696000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased ultrasonography (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>) use has been correlated with an increased incidence of pediatric renal cysts. For simple and stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> cysts, the malignancy risk is low in adulthood, no follow up is recommended; but there is no consensus on childhood management. Given that pediatric renal cysts may be manifestations of hereditary cystic diseases, a different approach and follow up should be taken for these patients. Herein we present the clinical characteristics and follow\u2010up data of pediatric patients with simple and stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> renal cysts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study involved 57 children (mean age, 12.44 \u00b1 3.65\u00a0years) with simple (<jats:italic>n<\/jats:italic> = 35) and stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> cysts (<jats:italic>n<\/jats:italic> = 22) who were diagnosed and followed at the present institution for \u22652\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up period was 2.84\u00a0years for simple and 3.10\u00a0years for stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> cysts. None of the patients developed complications. No change in cyst diameter was detected in 65.7% of simple or in 45.5% of stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> cysts, whereas 13 simple cysts (37.1%) and eight stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> cysts (36.4%) increased in diameter. The diameter change per year was significantly higher in the stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> cysts than in the simple cysts (<jats:italic>P<\/jats:italic> = 0.017). Overall, 13 patients (22%) had an estimated glomerular filtration rate &lt;90 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73 m<jats:sup>2<\/jats:sup>, and two patients had hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the malignancy risk of simple and stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> kidney cysts is low for this age group, potential complications such as renal dysfunction, hypertension and hereditary cystic disease should be closely monitored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13714","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T13:46:00Z","timestamp":1539611160000},"page":"1068-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Retrospective analysis of simple and stage <scp>II<\/scp> renal cysts: Pediatric nephrology point of view"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-4282","authenticated-orcid":false,"given":"Fehime Kara","family":"Eroglu","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-6206","authenticated-orcid":false,"given":"Evrim","family":"Karg\u0131n \u00c7ak\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5851-8676","authenticated-orcid":false,"given":"G\u00f6k\u00e7e","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fclin","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Yaz\u0131l\u0131ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda Didem","family":"Kurt\u2010Sukur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evra","family":"Celikkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"\u00dcner","sequence":"additional","affiliation":[{"name":"Department of Radiology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin","family":"\u00c7akmak\u00e7\u0131","sequence":"additional","affiliation":[{"name":"Department of Radiology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Dr Sami Ulus Maternity and Children's Health Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.08.055"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.04.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu106"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11111595"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017040421"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.03.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2015.04.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.03.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.178.2.1987597"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.063"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-873073"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.S2.555"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00678.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3364-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.02.349"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00651.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001784"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.481"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453078"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:32:29Z","timestamp":1694694749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/ped.13714"],"URL":"https:\/\/doi.org\/10.1111\/ped.13714","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}