{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:29:52Z","timestamp":1784215792174,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the clinical features of neonatal sepsis caused by <jats:italic>Citrobacter freundii<\/jats:italic> as well as the current status and treatment strategy for multi\u2010drug resistance of infection with this bacterium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine newborns were diagnosed with <jats:italic>C.\u00a0freundii<\/jats:italic> sepsis between January 2014 and December 2017. We collated and analyzed a range of data for these nine patients, including general information, laboratory tests during infection, blood culture and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One of the patients died after only 7\u00a0h of infection. In the remaining eight cases, three patients developed meningitis, although none had brain abscess. A reduction of white blood cells (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) was detected &lt;24\u00a0h after the start of infection, compared with at 48\u201372\u00a0h, when <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> count had increased and platelets progressively decreased. In all nine cases the infection was susceptible to tigecycline and was resistant to cephalosporins, carbapenems, and quinolones. In eight cases the infection was susceptible to co\u2010trimoxazole and in the other case it was susceptible to amikacin. Of the eight patients who were cured, three received meropenem, two received ceftriaxone, one received amikacin, and two received tigecycline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduction in <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> could take place in the early stages of <jats:italic>C.\u00a0freundii<\/jats:italic> infection in newborns. The incidence of brain abscess was not high, but multi\u2010drug resistance was common. Some non\u2010sensitive drugs can also treat <jats:italic>C.\u00a0freundii<\/jats:italic> sepsis effectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13715","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T14:05:30Z","timestamp":1539698730000},"page":"375-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["New insights into <i>Citrobacter freundii<\/i> sepsis in neonates"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-4327","authenticated-orcid":false,"given":"Dan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neonatology Shengjing Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalian","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shengjing Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.03.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/515106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000120561"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2012.10.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.2.191"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(03)00046-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310440023017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181b6b064"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4208-4215.1999"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.08.002"},{"issue":"1","key":"e_1_2_8_12_1","article-title":"Neonatal Citrobacter koseri meningitis and brain abscess","volume":"10","author":"Kariholu U","year":"2009","journal-title":"Internet J. 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