{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:13:17Z","timestamp":1788567197020,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labour Sciences Research Grant"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Very limited data are available on childhood gastric cancer. Using a retrospective survey and literature review, we assessed the clinical features of gastric cancer in children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected information on childhood gastric cancer from pediatricians of 518 hospitals that issue the title of \u201ccertified board pediatrician\u201d approved by Japan Pediatric Society, using a questionnaire on background, diagnosis year, onset symptoms, tumor location, histology, nodular gastritis, <jats:italic>Helicobacter pylori<\/jats:italic> testing, treatment, and prognosis. Studies were collected using PubMed and the <jats:styled-content style=\"fixed-case\">NPO<\/jats:styled-content> Japan Medical Abstracts Society database. Data for childhood gastric cancer were abstracted from the Japanese Vital Statistics database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 518 hospitals, 349 returned the questionnaire, which identified four patients. Literature review identified 77 cases of gastric cancer, and we analyzed data for 80 children &lt;16\u00a0years old. Most patients were &gt;10\u00a0years old, and there were no sex differences. Onset symptoms ranged from abdominal pain to non\u2010localized. Sixteen of 44 children had a family history of cancer; 10 had a family history of gastric cancer. Histologically, approximately 80% had undifferentiated\u2010type carcinoma. Prognosis was extremely poor, and two of three tested children were positive for <jats:italic>H.\u00a0pylori<\/jats:italic> infection. Childhood gastric cancer death has been declining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Childhood gastric cancer is rare in Japan, and information on <jats:italic>H.\u00a0pylori<\/jats:italic> in childhood gastric cancer patients is limited. Declining childhood gastric cancer rates may reflect the decreasing prevalence of infection but further study is necessary to clarify the relationship between <jats:italic>H.\u00a0pylori<\/jats:italic> and gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13720","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T16:49:42Z","timestamp":1541090982000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Gastric cancer in children and adolescents in Japan"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5263-2868","authenticated-orcid":false,"given":"Masumi","family":"Okuda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Aichi Medical University School of Medicine Nagakute Aichi Japan"},{"name":"Department of General Medicine and Community Health Science Hyogo College of Medicine Sasayama Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Toyama Toyama Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Hakodate Hospital Hakodate Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingsong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Public Health Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Mabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Hakodate Hospital Hakodate Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-2857","authenticated-orcid":false,"given":"Akihisa","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Public Health Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Cancer Registry and Statistics. 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