{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:15:35Z","timestamp":1791389735373,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the modern era of chemotherapy, the outcome of pediatric non\u2010Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) continues to improve internationally. Limited data such as information on epidemiology and survival, however, are available in Asian countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children (\u226415\u00a0years old) diagnosed with histologically proven <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> from 1998 to 2014 were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 114 patients were enrolled; they were predominantly male (65.8%) and had advanced disease (stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IV<\/jats:styled-content>; 71.9%). Of these, 22.8% had Burkitt lymphoma, 20.2% had diffuse large B\u2010cell lymphoma, 21.1% had lymphoblastic lymphoma, 20.2% had large cell lymphoma, and 15.8% had peripheral T\u2010cell lymphoma. Twenty\u2010nine patients died, especially of uncontrolled disease (62.1%) and infection (20.7%). During a median follow up of 78.4\u00a0months, Kaplan\u2013Meier 5\u00a0year event\u2010free and overall survival rates were 71.5% \u00b1 4.3% and 74.8% \u00b1 4.1%, respectively, regardless of subtype. B symptoms (i.e. systemic symptoms of fever, night sweats, and weight loss that can be associated with both Hodgkin's lymphoma and non\u2010Hodgkin's lymphoma) and advanced disease had a significant negative impact on 5\u00a0year survival. No other prognostic factor was found, but survival tended to have a negative correlation with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pediatric <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> is aggressive, with a high prevalence of peripheral T\u2010cell lymphoma. The present treatment stratification seems to be effective compared with that used in developed countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13739","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T08:31:24Z","timestamp":1549614684000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pediatric non\u2010Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-2918","authenticated-orcid":false,"given":"Worawut","family":"Choeyprasert","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usanarat","family":"Anurathapan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samart","family":"Pakakasama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nongnuch","family":"Sirachainan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duantida","family":"Songdej","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surapong","family":"Lertthammakiat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suradej","family":"Hongeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"978","article-title":"Malignant non\u2010Hodgkin's lymphoma of childhood and adolescence in Austria: therapy results between 1986 and 2000","volume":"114","author":"Attarbaschi A","year":"2002","journal-title":"Wien. 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