{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:09:03Z","timestamp":1785370143631,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Central venous (<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>) catheters are required for chemotherapy but they may become a source of life\u2010threatening infections of the bloodstream. The most effective way to disinfect the port of a <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> catheter has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report the data obtained between April 2008 and March 2010 using 83% ethanol (period I) and between April 2010 and March 2014 using 10% povidone\u2010iodine (period <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) to sterilize the access port. The participants received chemotherapy or autologous\/allogeneic stem cell transplantation at the present institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was observed in patient characteristics between the two periods, such as disease, median age, or the period of neutropenia. The incidence of positive blood culture during periods I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> was 18.5% (31\/168) and 11.4% (40\/350; <jats:italic>P<\/jats:italic> = 0.041), respectively. The incidence of catheter\u2010associated bloodstream infection on blood culture during periods I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> was 11.9% (20\/168) and 6.3% (22\/350; <jats:italic>P<\/jats:italic> = 0.043), respectively. <jats:italic>Bacillus cereus<\/jats:italic> infection was not detected during period <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of infection caused by <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> catheters was significantly reduced using povidone\u2010iodine; therefore, we recommend this procedure as part of the routine in chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13759","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T15:42:58Z","timestamp":1545320578000},"page":"230-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Povidone\u2010iodine lowers the incidence of catheter\u2010associated bloodstream infection"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-2097","authenticated-orcid":false,"given":"Minako","family":"Sugiyama","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukayo","family":"Terashita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiro","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20130009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1652-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2004.03.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.19.2066"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231709"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4406-4"},{"key":"e_1_2_8_8_1","unstructured":"Centers for Disease Control and Prevention.Guidelines for the Prevention of Intravascular Catheter\u2010Related Infections2011. [Cited 2011] Available from:https:\/\/www.cdc.gov\/infectioncontrol\/guidelines\/pdf\/bsi\/bsi-guidelines-H.pdf"},{"key":"e_1_2_8_9_1","unstructured":"Centers for Disease Control and Prevention.Guidelines for the Prevention of Intravascular Catheter\u2010Related Infections2002. [Cited 9 August 2002.] Available from:https:\/\/www.cdc.gov\/mmwr\/PDF\/rr\/rr5110.pdf"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.738"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24135"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25101"},{"issue":"6","key":"e_1_2_8_13_1","first-page":"CD010336","article-title":"Antibiotic lock for the prevention of catheter\u2010related infection in neonates","author":"Taylor JE","year":"2015","journal-title":"Cochrane Database Syst. 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