{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:08:11Z","timestamp":1790316491516,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bezmialem Vakif University Scientific Research Projects Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adipokines have been suggested to play an important role in the pathogenesis of polycystic ovarian syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). Omentin is an adipokine secreted essentially by visceral adipose tissue with an insulin\u2010sensitizing effect. Insulin resistance (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) is a common feature of <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, therefore the aim of this study was to investigate omentin\u20101 level in adolescent girls with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and its relationship with <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and androgens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 41 obese girls with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, and 30 age\u2010 and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>)\u2010matched obese girls without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> were enrolled in the study. The demographic, clinic and laboratory characteristics of the groups were compared. Additionally, bivariate correlation analysis of omentin\u20101 with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> standard deviation score (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SDS<\/jats:styled-content>), insulin, glucose, homeostatic model assessment of <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>), total and free testosterone was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> group <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, free and total testosterone were higher than in the control group. Omentin\u20101 was lower in the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> group compared with the controls (55.01 \u00b1 7.99\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> vs 59.10 \u00b1 7.02\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively; <jats:italic>P<\/jats:italic> = 0.027). Omentin\u20101 was inversely correlated with free testosterone (<jats:italic>r<\/jats:italic> = \u22120.527, <jats:italic>P<\/jats:italic> = 0.030) and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SDS<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = \u22120.241, <jats:italic>P<\/jats:italic> = 0.046) but it was not correlated with total testosterone, <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, glucose, insulin or serum lipids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Omentin\u20101 was lower in obese girls with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and hyperandrogenism was associated with this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13761","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T15:20:21Z","timestamp":1545232821000},"page":"147-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Omentin\u20101 level in adolescents with polycystic ovarian syndrome"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-9652","authenticated-orcid":false,"given":"\u0130lker Tolga","family":"\u00d6zgen","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology Faculty of Medicine Bezmialem Vakif University Fatih, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e\u00fcera","family":"Oru\u00e7lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Bezmialem Vakif University Fatih, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahabettin","family":"Selek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Bezmialem Vakif University Fatih, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-1631","authenticated-orcid":false,"given":"Esra","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology Faculty of Medicine Bezmialem Vakif University Fatih, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcls\u00fcm","family":"Guzel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Bezmialem Vakif University Fatih, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u015far","family":"Cesur","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology Faculty of Medicine Bezmialem Vakif University Fatih, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9513"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00572.2004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1355338"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479371"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.3.e29"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02206.x"},{"key":"e_1_2_8_8_1","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole TJ","year":"1990","journal-title":"Eur. J. Clin. Nutr."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v2i3.100"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.9.1165"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.02.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590400007309"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"17820","DOI":"10.1016\/S0021-9258(18)38237-1","article-title":"An insulin\u2010like growth factor I\/insulin hybrid exhibiting high potency for interaction with the type I insulin\u2010like growth factor and insulin receptors of placental plasma membranes","volume":"265","author":"Cara JF","year":"1990","journal-title":"J. Biol. Chem."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.suppl_1.53"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.019646"},{"key":"e_1_2_8_17_1","first-page":"755","article-title":"Relationship between insulin sensitivity and circulating sex hormone\u2010binding globulin levels in hyperandrogenic obese women","volume":"18","author":"Fendri S","year":"1994","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049972"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0375"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12381"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.650747"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0990"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.15386\/cjm.2014.8872.871.afc1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det097"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3414"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:58:22Z","timestamp":1694692702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/ped.13761"],"URL":"https:\/\/doi.org\/10.1111\/ped.13761","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"2018-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}