{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:47:52Z","timestamp":1770349672709,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood sodium and ketone are parameters of dehydration and fasting, respectively. Little is known, however, about the postnatal changes in these parameters in healthy, term, exclusively breast\u2010fed neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Capillary blood sodium, \u03b2\u2010hydroxybutyrate (\u03b2\u2010<jats:styled-content style=\"fixed-case\">OHB<\/jats:styled-content>), and glucose levels in 628 samples obtained from 392 healthy, term, exclusively breast\u2010fed neonates during the first 12\u2013143\u00a0h of life were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood sodium and \u03b2\u2010<jats:styled-content style=\"fixed-case\">OHB<\/jats:styled-content> gradually increased and reached a peak at 48\u201359\u00a0h of life (mean blood sodium, 142.3 \u00b1 2.8 <jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L; mean blood sodium increase, 3.3 <jats:styled-content style=\"fixed-case\">mE<\/jats:styled-content>q\/L; mean \u03b2\u2010<jats:styled-content style=\"fixed-case\">OHB<\/jats:styled-content>, 1.16 \u00b1 0.46\u00a0mmol\/L; mean \u03b2\u2010<jats:styled-content style=\"fixed-case\">OHB<\/jats:styled-content> increase, 0.65\u00a0mmol\/L), and then gradually decreased and reached a nadir at 120\u2013143\u00a0h of life. Blood glucose gradually decreased and reached a nadir at 48\u201359\u00a0h of life (mean, 62.4 \u00b1 12.2\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>; mean decrease, 4.7\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>), and then gradually increased and peaked at 120\u2013143\u00a0h of life. These changes were synchronized with changes in weight\u2010loss percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The postnatal changes in blood sodium, ketone, and glucose levels during the first 12\u2013143\u00a0h of life are described in healthy, term, exclusively breast\u2010fed neonates. The parameters seemed to be associated with the sufficiency of the breast\u2010milk supply. These results can serve as normal reference values for healthy, term, exclusively breast\u2010fed neonates during the early postnatal period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13824","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T01:28:18Z","timestamp":1552267698000},"page":"471-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exclusive breast\u2010feeding and postnatal changes in blood sodium, ketone, and glucose levels"],"prefix":"10.1111","volume":"61","author":[{"given":"Takeshi","family":"Futatani","sequence":"first","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihomi","family":"Ina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Shimao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Higashiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-3515","authenticated-orcid":false,"given":"Shuhei","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Hatasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.095497"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2012.02529.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0841-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.607"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.4.318"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.08.080"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.108415"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2491"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80588-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.05.051"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.4_Spec_No.357"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1532"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118880"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01528.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.4.1137"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.351"},{"key":"e_1_2_7_18_1","first-page":"316293","article-title":"Point\u2010of\u2010care measurements of blood ketones in newborns","author":"Harris DL","year":"2018","journal-title":"Arch. 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