{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:36:07Z","timestamp":1792503367036,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a high incidence of intraventricular hemorrhage in extremely low\u2010birthweight (<jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content>) infants of low gestational age with high\u2010grade fluctuations in the perfusion waveform of the internal cerebral vein. This study investigated changes in the hemodynamic status of <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants during initial strong fluctuations in the perfusion waveform of the internal cerebral vein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the perfusion waveform of the internal cerebral vein in 192 <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants from birth, every 8\u00a0h for a total of 120\u00a0h. Sixty\u2010seven infants had high\u2010grade fluctuations. On the basis of the presence of patent ductus arteriosus (<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>), patients were subdivided into <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>(\u2212) (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) and <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>(+) (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the first high\u2010grade fluctuation, the <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>(\u2212) group had significant increases in systolic, diastolic, and mean blood pressure (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for all). The <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>(+) group did not have significant changes in blood pressure but did have significant increases in the number of interruptions or regurgitations of diastolic renal arterial blood flow (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) and end\u2010diastolic left pulmonary arterial flow velocity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), indicating increased left\u2010to\u2010right shunt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Blood pressure elevation may underlie fluctuations in the perfusion waveform of the internal cerebral vein and lead to the first high\u2010grade increases during acute management of <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants. When no elevation in blood pressure occurred, hemodynamically significant <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> was considered a potential underlying factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13828","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T01:28:45Z","timestamp":1552267725000},"page":"475-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hemodynamics of infants with strong fluctuations of internal cerebral vein"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-1958","authenticated-orcid":false,"given":"Toshifumi","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Neonatology Aomori Prefectural Central Hospital Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Neonatology Aomori Prefectural Central Hospital Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Neonatology Aomori Prefectural Central Hospital Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Neonatology Aomori Prefectural Central Hospital Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Neonatology Aomori Prefectural Central Hospital Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Yamoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Aomori Prefectural Central Hospital Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Neurology of the Newborn","author":"Volpe JJ","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0372"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.04.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2396-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.10_Spec_No.1169"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198506000-00012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444311822"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.43.4.480"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80397-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90503-7"},{"key":"e_1_2_8_15_1","first-page":"CD000174","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","volume":"7","author":"Fowlie PW","year":"2010","journal-title":"Cochrane Database Syst. 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