{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:56:36Z","timestamp":1780512996826,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H24\u2010Nanchi\u2010Ippan\u2010034, 2002"],"award-info":[{"award-number":["H24\u2010Nanchi\u2010Ippan\u2010034, 2002"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The optimum enteral (EN<\/jats:styled-content>) and parenteral nutrition (PN<\/jats:styled-content>) regimens during acute management of congenital diaphragmatic hernia (CDH<\/jats:styled-content>) remain unclear. We examined the effects of EN<\/jats:styled-content> and PN<\/jats:styled-content> on weight gain in CDH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>A multicenter retrospective cohort study of neonates with CDH<\/jats:styled-content> (born 2006\u20132010; n<\/jats:italic> = 105) who survived to discharge was conducted. Patients were divided as receiving PN<\/jats:styled-content> \u2265 or <50 kcal\/kg\/day at 1 week of age, and EN<\/jats:styled-content> \u2265 or <60 kcal\/kg\/day at 2 weeks of age. Changes in bodyweight at 30, 60, and 90 days of age were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>The higher EN<\/jats:styled-content> group (n<\/jats:italic> = 39) had greater mean weight gain than the lower EN<\/jats:styled-content> group (n<\/jats:italic> = 66; 90 days: 2,501 g, 95% CI<\/jats:styled-content>: 2,294\u20132,710 g vs 1,706 g, 95% CI<\/jats:styled-content>: 1,553\u20131,861 g; P<\/jats:italic> <0.001). When patients received lower EN<\/jats:styled-content>, the higher PN<\/jats:styled-content> group (n<\/jats:italic> = 24) had greater mean weight gain than the lower PN<\/jats:styled-content> group (n<\/jats:italic> = 42; 90 days: 1,768 g, 95% CI<\/jats:styled-content>: 1,574\u20131,961 g vs 1,411 g, 95% CI<\/jats:styled-content>: 1,264\u20131,558 g; P<\/jats:italic> = 0.004).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The amount of EN<\/jats:styled-content> in the acute phase of CDH<\/jats:styled-content> management is essential for weight gain during infancy. When patients are intolerant to adequate EN<\/jats:styled-content>, supportive PN<\/jats:styled-content> is also essential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13837","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T03:13:25Z","timestamp":1553051605000},"page":"482-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of nutrition in the treatment of congenital diaphragmatic hernia"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-5179","authenticated-orcid":false,"given":"Keita","family":"Terui","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka Women's and Children's Hospital Izumi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tazuke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medical Sciences Kyushu University Higashi Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miharu","family":"Ito","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Neonatal Care Nagoya University Hospital Showa Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroomi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Neonatal Care Nagoya University Hospital Showa Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medical Sciences Kyushu University Higashi Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Keio University School of Medicine Shinjuku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"60","article-title":"Growth assessment and the risk of growth retardation in congenital diaphragmatic hernia: A long\u2010term follow\u2010up study from the Japanese Congenital Diaphragmatic Hernia Study Group","volume":"26","author":"Terui K","year":"2016","journal-title":"Eur. 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