{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:33:16Z","timestamp":1793251996939,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognosis of high\u2010risk neuroblastoma stage 4 with bone marrow metastasis, <jats:styled-content style=\"fixed-case\">MYCN<\/jats:styled-content> amplified, or refractory neuroblastoma is poor. To date, no standard treatment has been established. In four selected cases, we challenged the killer\u2010cell immunoglobulin\u2010like receptor ligand mismatch cord blood transplantation in graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>) with reduced\u2010intensity conditioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prior to this study, conventional chemotherapy, autologous peripheral blood stem cell transplantation with high\u2010dose chemotherapy (busulfan and melphalan), surgery and radiation therapy were completed in every case. The status before cord blood transplantation in two cases was not complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) and in the others it was <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>. The primary site was the mediastinum, two adrenal glands and a retroperitoneum, respectively. Three patients had bone and bone marrow metastasis and one had <jats:styled-content style=\"fixed-case\">MYCN<\/jats:styled-content> amplification. In all cases, international neuroblastoma pathology classification was unfavorable histology. All patients were &gt;2 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relapse occurred only in one patient 17 months after the last transplantation, and the other three patients maintained disease\u2010free survival for 74, 36, and 24 months, respectively. In one case of relapse the disease could be controlled by conventional chemotherapy. Except one, all patients had no severe complications, such as acute or chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>. One patient had gastric antral vascular ectasia and hemorrhagic cystitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This strategy might be feasible and should be investigated for efficacy in the future. No definite conclusion can be made, however, due to the very small number of patients. Further prospective studies are required to determine its efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13861","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T06:19:12Z","timestamp":1555049952000},"page":"566-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Killer\u2010cell immunoglobulin\u2010like receptor ligand mismatch cord blood transplantation in high\u2010risk neuroblastoma"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-4760","authenticated-orcid":false,"given":"Ryosuke","family":"Matsuno","sequence":"first","affiliation":[{"name":"Department of Pediatrics Showa University Fujigaoka Hospital Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University Fujigaoka Hospital Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University Fujigaoka Hospital Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Isoyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University Fujigaoka Hospital Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Shiozawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Showa University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Showa University Fujigaoka Hospital Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910143411601"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70291-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200211000-00004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24433"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911123"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6986"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.3484"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.11.2382"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704070"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705681"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1582"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-077438"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-065383"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.365"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1720"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.10.056"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10375"},{"key":"e_1_2_7_20_1","first-page":"135","article-title":"Efficacy of combination chemotherapy consisting of irinotecan, etoposide, and carboplatin (IREC) in children with refractory solid tumors","volume":"44","author":"Inoue M","year":"2007","journal-title":"Jpn. 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