{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:52:41Z","timestamp":1747187561125,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010emptive kidney transplantation (<jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content>) is beneficial for patients, improves graft survival and minimizes the complications associated with chronic kidney disease. Reports on pediatric <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content>, however, are limited, and little is known about the parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) abnormalities and calcium\u2013phosphorus disorders (<jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content>) in this condition. This study was the first to report on mineral disorders in pediatric <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> patients during a 1\u00a0year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a comparative examination of the abnormalities in calcium, phosphorus, calcium\u2013phosphorus products and <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> before and 1\u00a0year after living donor kidney transplantation in <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients were included. The patients were divided into two groups: <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 11; 5\u00a0months in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 4\u20135) and non\u2010<jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 20; 31.5\u00a0months in dialysis). Mean age at transplantation was 9.4 \u00b1 5.0\u00a0years. Hypercalcemia and hyperphosphatemia were observed before and after transplantation in the <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> groups, and &gt;15% of patients in each group had bone disorder and ectopic calcification associated with mineral disorder. Mineral disorder was present for approximately 3\u00a0months after transplantation in both treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant differences in <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content> were noted between PEKT and non\u2010PEKT groups; moreover, normalization of abnormal values did not differ between the <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> groups. Compared with non\u2010<jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PEKT<\/jats:styled-content> did not improve the course of mineral metabolism disorders. Mineral and bone disorder treatment was likely insufficiently provided to pediatric <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content> patients. To obtain the maximum advantage of <jats:styled-content style=\"fixed-case\">PEKT<\/jats:styled-content>, calcium and phosphorus levels should be strictly controlled before kidney transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13875","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T17:23:59Z","timestamp":1556817839000},"page":"587-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mineral disorders in pediatric pre\u2010emptive kidney transplantation"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-6746","authenticated-orcid":false,"given":"Kei","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Toho University Medical Center Omori Hospital Ota City Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Motoyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toho University Medical Center Sakura Hospital Sakura Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichiro","family":"Shishido","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Toho University Medical Center Omori Hospital Ota City Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology Toho University Medical Center Omori Hospital Ota City Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"178","article-title":"Vascular calcification in a young patient with end\u2010stage renal disease","volume":"19","author":"Chan WK","year":"2013","journal-title":"Hong Kong Med. 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