{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:54:31Z","timestamp":1790463271102,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Outbreaks of enterovirus D68 (<jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68) respiratory infections in children were reported globally in 2014. In Japan, there was an <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68 outbreak in the autumn of 2015 (September\u2013October). The aim of this study was to compare <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68\u2010specific polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>)\u2010positive and <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010negative patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pediatric patients admitted for any respiratory symptoms between September and October 2015 were enrolled. Nasopharyngeal swabs were tested for multiplex respiratory virus <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68\u2010specific reverse transcription\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010positive and \u2010negative patients were compared regarding demographic data and clinical information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A nasopharyngeal swab was obtained from 76 of 165 patients admitted with respiratory symptoms during the study period. <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68 was detected in 40 samples (52.6%). Median age in the <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010positive and \u2010negative groups was 3.0\u00a0years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 5.5\u00a0years) and 3.0\u00a0years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 4.0\u00a0years), respectively. The rates of coinfection in the two groups were 32.5% and 47.2%, respectively. There was no significant difference in the history of asthma or recurrent wheezing, length of hospitalization, or pediatric intensive care unit admission rate between the groups. The median days between symptom onset and admission was significantly lower for the <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68\u2010positive group (3.0\u00a0days vs 5.0\u00a0days, <jats:italic>P<\/jats:italic> = 0.001). <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68 was identified as clade B on phylogenetic analysis. No cases of acute flaccid myelitis were encountered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than half of the samples from the children admitted with respiratory symptoms were positive for <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>\u2010D68\u2010specific <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> during the outbreak. Asthma history was not associated with the risk of developing severe respiratory infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13903","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:03:20Z","timestamp":1559052200000},"page":"768-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Enterovirus D68 respiratory infection in a children's hospital in Japan in 2015"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-0719","authenticated-orcid":false,"given":"Yu","family":"Funakoshi","sequence":"first","affiliation":[{"name":"Department of General Pediatrics Tokyo Metropolitan Children's Medical Center Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Tokyo Metropolitan 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