{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:20:00Z","timestamp":1789014000625,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18K07885"],"award-info":[{"award-number":["18K07885"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18K15726"],"award-info":[{"award-number":["18K15726"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Global hemostatic mechanism(s) in patients with disseminated intravascular coagulation (DIC) are poorly understood. There are few diagnostic criteria of DIC based on overall or global hemostatic mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have assessed in detailed the dynamic global hemostatic changes using thrombin and plasmin generation assay (T\/P\u2010GA), clot fibrinolytic waveform analysis (CFWA) and not\u2010activated rotational thromboelastometry (NATEM), in a young girl with DIC associated with acute myeloid leukemia (AML). The ratios of endogenous thrombin potential (T\u2010EP) and plasmin lag time (P\u2010LT) relative to normal plasma was sourced from pooled normal plasma from healthy volunteers on T\/P\u2010GA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The inverse P\u2010LT ratio prior to tranexamic acid (TXA) treatment was greater than the T\u2010EP ratio (1.1\u20132.8 and 0.83\u20131.2, respectively). Significant reduction in inverse P\u2010LT ratio (0.084\u20131.3) was observed after TXA treatment. The interval from clotting to the initiation of fibrinolysis (fibrinolysis lag time: FLT) in CFWA was significantly shorter than the control at onset (74.2\u201391.6\u00a0s vs 109\u00a0s), indicating enhanced fibrinolysis. Data from an adult with acute promyelocytic leukemia\u2010associated DIC also supportively showed a high inverse P\u2010LT ratio (2.1) and shortened FLT (83.7\u00a0s). The clotting time in patient whole blood using NATEM\u2010mode during an episode of severe epistaxis markedly shortened beyond control, but returned to normal after the addition of an anti\u2010tissue factor (TF) monoclonal antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The release of intravascular TF contributed to sustained activation of coagulation and subsequent fibrinolytic activity in this patient with AML\u2010associated DIC, and T\/P\u2010GA could provide better quantitative data than conventional assays in these circumstances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13919","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T22:49:16Z","timestamp":1561243756000},"page":"872-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hemostatic function in hyperfibrinolytic disseminated intravascular coagulation"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-085X","authenticated-orcid":false,"given":"Takashi","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Nogami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ogiwara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ochi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Central Clinical Laboratory Nara Medical University Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2052-0492-2-20"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2012.04.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.08.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25855"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.191"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600572673"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23581"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009053534"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01550.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/107602960000600102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(93)90054-O"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02270-8.x"},{"key":"e_1_2_8_14_1","first-page":"1113","article-title":"Fatal thromboembolism in acute promyelocytic leukemia during all\u2010trans retinoic acid therapy combined with antifibrinolytic therapy for prophylaxis of hemorrhage","volume":"8","author":"Hashimoto S","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2213-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13546"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-04-0345"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16111"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12987"},{"key":"e_1_2_8_20_1","first-page":"265","article-title":"Criteria for diagnosis of DIC based on the analysis of clinical and laboratory findings in 345 DIC patients collected by the Research Committee on DIC in Japan","volume":"49","author":"Kobayashi N","year":"1983","journal-title":"Bibl. 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