{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:52:47Z","timestamp":1747187567285,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alveolar soft\u2010part sarcoma (<jats:styled-content style=\"fixed-case\">ASPS<\/jats:styled-content>) is an uncommon malignancy that may present in a manner similar to benign vascular tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 6\u2010year\u2010old boy with autism spectrum disorder was referred to the Johns Hopkins All Children's Hospital vascular anomalies clinic for the evaluation of a tongue mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to the presentation, at 5\u00a0years of age, neck computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) was performed. This showed a well circumscribed, enhancing mass at the anterior aspect of the tongue. The radiologic impression was that this lesion was most likely a hemangioma. Two years later, the patient was evaluated in the vascular anomalies clinic. At that examination a 2\u20133\u00a0cm swelling was noted on the dorsal aspect of the tongue. The mass was fleshy and firm with discrete borders. Handheld Doppler examination indicated a high\u2010flow lesion. The patient underwent an excisional biopsy. The lesion was identified as an alveolar soft\u2010part sarcoma based on pathologic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Familiarity with common vascular tumors and malformations allows providers to diagnose the majority of these lesions on a combination of clinical history and physical examination. Atypical and combined lesions do benefit from imaging to help characterize and aid in the differential diagnosis. Biopsy enables definitive diagnosis but is necessary in the minority of cases. When in doubt, referral to a specialized, multidisciplinary vascular anomalies clinic will ensure that these patients receive management for this challenging collection of conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13920","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T13:58:13Z","timestamp":1561039093000},"page":"978-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Alveolar soft\u2010part sarcoma: Case demonstrating principles for uncommon vascular lesions"],"prefix":"10.1111","volume":"61","author":[{"given":"Maria","family":"Leszczynska","sequence":"first","affiliation":[{"name":"Department of General Pediatrics Johns Hopkins All Children's Hospital St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-0041","authenticated-orcid":false,"given":"Diana S","family":"Jodeh","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Johns Hopkins All Children's Hospital St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damon","family":"Reed","sequence":"additional","affiliation":[{"name":"Cancer and Blood Disorders Institute Johns Hopkins All Children's Hospital St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa M","family":"Lynskey","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Johns Hopkins All Children's Hospital St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Bittles","sequence":"additional","affiliation":[{"name":"Department of Radiology Johns Hopkins All Children's Hospital St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer LR","family":"Mayer","sequence":"additional","affiliation":[{"name":"Cancer and Blood Disorders Institute Johns Hopkins All Children's Hospital St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-1966","authenticated-orcid":false,"given":"S Alex","family":"Rottgers","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Johns Hopkins All Children's Hospital St Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v6.i9.677"},{"key":"e_1_2_7_3_1","first-page":"9","volume-title":"Vascular Anomalies: Classification, Diagnosis, and Management","author":"Greene AK","year":"2013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.05.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890101)63:1<1::AID-CNCR2820630102>3.0.CO;2-E"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27405"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2010.08.014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.315105213"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20130392"},{"key":"e_1_2_7_10_1","unstructured":"International Society for the Study of Vascular Anomalies.Classification 2018; Available at:http:\/\/www.issva.org\/UserFiles\/file\/ISSVA-Classification-2018.pdf. Accessed August 23 2018."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198203000-00002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117241"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00626.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196607000-00013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2767"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2485"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2015.04.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1376260"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318208d2ac"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.670"},{"key":"e_1_2_7_21_1","first-page":"1120","volume-title":"Soft Tissue Tumours","author":"Enzinger F","year":"1995"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/907179"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26953"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010201)91:3<585::AID-CNCR1038>3.0.CO;2-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3766"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0037"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx774"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.031120"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199602)26:2<81::AID-MPO2>3.0.CO;2-Q"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.13920","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T16:44:04Z","timestamp":1694191444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/ped.13920"],"URL":"https:\/\/doi.org\/10.1111\/ped.13920","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}