{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:05:42Z","timestamp":1787162742632,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study evaluated potential risk factors associated with acute kidney injury (\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      ) in infants undergoing bedside open laparotomy in the neonatal intensive care unit (NICU), and analyzed the association between postoperative\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      and outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data, including neonatal characteristics, perioperative findings (i.e. vital signs and fluid status), postoperative AKI incidence, and postoperative mortality rate of infants who underwent bedside open laparotomy in the NICU between May 2013 and May 2018 were collected and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 53 cases (26 in\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      group vs 27 in non\u2010\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      group) were analyzed. On univariable analysis, transfusion, pre\u2010 and postoperative blood gas analysis and number of inotropic agents, cumulative postoperative percentage fluid overload (48\u00a0h), and preoperative hourly urine output were associated with the development of postoperative\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      . On multivariable logistic regression analysis, preoperative acidosis (\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      &lt;7.15 or base deficit &gt;10;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002; OR, 11.067; 95%CI: 2.499\u201349.017) and preoperative urine output (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.035;\n                      <jats:styled-content style=\"fixed-case\">OR,<\/jats:styled-content>\n                      0.548; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.314\u20130.959) were significant factors associated with postoperative\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      . Postoperative mortality rate 30\u00a0days after surgery was higher in the\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      group, but the difference was not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Preoperative metabolic acidosis and urine output are important factors potentially associated with the development of postoperative\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      in neonates undergoing bedside open laparotomy. Strategies such as alkali therapy, which protect the kidney from further injury, should be validated in future studies. A decreasing urine output may suggest deteriorating kidney function prior to surgery, potentially amplifying the risk of postoperative\n                      <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.13929","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T03:28:41Z","timestamp":1562124521000},"page":"994-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preoperative metabolic acidosis and acute kidney injury after open laparotomy in the neonatal intensive care unit"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8589-3159","authenticated-orcid":false,"given":"Sook Kyung","family":"Yum","sequence":"first","affiliation":[{"name":"Department of Pediatrics College of Medicine Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Mi","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Ah","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Kyung","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135116648305"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135115586814"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1655-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2638-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002231"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_7_9_1","first-page":"SC01","article-title":"Clinical profile and outcome of newborns with acute kidney injury in a level 3 neonatal unit in western India","volume":"11","author":"Bansal SC","year":"2017","journal-title":"J. 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