{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:52:52Z","timestamp":1747187572504,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Late\u2010onset circulatory collapse (LCC<\/jats:styled-content>) is the transient development of refractory hypotension and oliguria after the early neonatal period, which may cause periventricular leukomalacia (PVL<\/jats:styled-content>). The aim of this study was to evaluate the endogenous cortisol response to corticotrophin\u2010releasing hormone (CRH<\/jats:styled-content>) and determine whether it is effective for elucidating the pathology and selecting treatment in LCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective study examined infants admitted to the neonatal intensive care unit. Included were preterm (gestational age <34 weeks) infants who underwent CRH<\/jats:styled-content> stimulation test and were treated for LCC<\/jats:styled-content> with no obvious cause. Hydrocortisone (HC<\/jats:styled-content>; 3.3\u201310 mg\/kg) was given by bolus injection to the LCC<\/jats:styled-content> infants. At 2 h after treatment, infants without a 20% rise in blood pressure (systolic or mean) from before treatment were defined as non\u2010responsive to HC<\/jats:styled-content>, and given catecholamine and\/or vasopressin.<\/jats:p><\/jats:sec>Results<\/jats:title>Sixteen infants (median gestational age, 24 weeks 3 days; birthweight, 638 g) were eligible. Six of the infants had a good response to the CRH<\/jats:styled-content> stimulation test. HC<\/jats:styled-content> was effective in only three CRH good\u2010response cases, and catecholamine and\/or vasopressin was needed in the three other cases. HC<\/jats:styled-content> was effective, however, for all CRH non\u2010response cases.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Although HC<\/jats:styled-content> is the first\u2010choice treatment for LCC<\/jats:styled-content>, the CRH<\/jats:styled-content> stimulation test facilitates prompt treatment of LCC<\/jats:styled-content>, which may prevent PVL<\/jats:styled-content>. The present findings help elucidate the pathology and aid in the selection of treatment for infants with LCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13956","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T02:57:38Z","timestamp":1562554658000},"page":"1114-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Corticotrophin\u2010releasing hormone stimulation tests in late\u2010onset circulatory collapse"],"prefix":"10.1111","volume":"61","author":[{"given":"Hiroko","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Perinatal and Neonatal Medicine Aichi Medical University Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5557-0439","authenticated-orcid":false,"given":"Hiroki","family":"Kakita","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Neonatal Medicine Aichi Medical University Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Neonatal Medicine Aichi Medical University Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Neonatal Medicine Aichi Medical University Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Neonatal Medicine Aichi Medical University Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatenobu","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Neonatal Medicine Aichi Medical University Nagakute Aichi 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