{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:06:46Z","timestamp":1784740006349,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human calmodulin (CALM) gene mutation has been reported to be related to inherited arrhythmia syndromes, but the genotype\u2013phenotype relationship remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We report here a 4\u2010year\u2010old boy who had cardiac arrest while playing in a kindergarten playground. Cardiopulmonary resuscitation was initiated immediately. Eleven minutes after the cardiac arrest, ambulance crews arrived and an automated external defibrillator was attached. His heart rhythm, which was ventricular fibrillation (VF), was returned to sinus rhythm after only one shock delivery. The boy was brought to hospital by air ambulance. During transfer, electrocardiogram (ECG) showed transient VF. On arrival, chest radiograph showed a cardiothoracic ratio of 55% without pulmonary congestion. A 12\u2010lead ECG showed a normal sinus rhythm, biphasic T wave, and prolongation of the corrected QT interval. On ECG, VF was preceded by torsade de pointes or frequent polymorphic premature ventricular contractions (PVC). Echocardiography showed a normal heart structure with decreased cardiac function. On the second day of hospitalization, ECG showed remarkable QT prolongation, T\u2010wave alternans, and frequent PVC. Thereafter, propranolol was started. The ECG showed rapid improvement of QT prolongation and T\u2010wave abnormality. Genetic test indicated a <jats:italic>CALM2<\/jats:italic> mutation, and he was diagnosed with long QT syndrome\u201015 (LQT15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>CALM<\/jats:italic> mutations cause long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT) and idiopathic VF. This patient with a <jats:italic>CALM2<\/jats:italic> p.N98S mutation had both phenotypes of LQTS and CPVT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13959","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T16:19:12Z","timestamp":1562602752000},"page":"852-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long QT syndrome with a de novo <i>CALM2<\/i> mutation in a 4\u2010year\u2010old boy"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-3515","authenticated-orcid":false,"given":"Shuhei","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-8988","authenticated-orcid":false,"given":"Ryo","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Futatani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Fuchigami","sequence":"additional","affiliation":[{"name":"Department of Emergency Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Emergency Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine Shiga University of Medical Science Otsu Shiga Japan"},{"name":"Department of Bioscience and Genetics National Cerebral and Cardiovascular Center Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine Shiga University of Medical Science Otsu Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hatasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyama 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001216"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2016.02.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153851"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000459"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.091"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0905"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.08.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.10.035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.044"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303391"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx073"}],"container-title":["Pediatrics 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