{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:52:59Z","timestamp":1747187579646,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["2017\u20102\u00a0+\u00a0018"],"award-info":[{"award-number":["2017\u20102\u00a0+\u00a0018"]}],"id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Interferon\u2010\u03b3 (IFN<\/jats:styled-content>\u2010\u03b3) and interleukin\u201012 (IL<\/jats:styled-content>\u201012) play a crucial role in the defense against mycobacteria, and in the response to bacillus Calmette\u2013Gu\u00e9rin (BCG<\/jats:styled-content>) vaccination. We have previously reported clinical and outcome data of 222 BCG<\/jats:styled-content> osteitis cases diagnosed in 1960\u20131988 in Finland. The immunological and genetic reports have been based on 132 blood samples obtained in 2007\u20132008.<\/jats:p><\/jats:sec>Methods<\/jats:title>We compared IFN<\/jats:styled-content>\u03b3<\/jats:italic> rs2430561<\/jats:ext-link> and rs35314021<\/jats:ext-link>, IL<\/jats:styled-content>12A<\/jats:italic> rs568408<\/jats:ext-link> and rs2243115<\/jats:ext-link>, and IL<\/jats:styled-content>12B<\/jats:italic> rs3212227<\/jats:ext-link> single\u2010nucleotide polymorphisms (SNP<\/jats:styled-content>) between 132 BCG<\/jats:styled-content> osteitis patients and 99 population\u2010based controls. In addition, stimulated production of IFN<\/jats:styled-content>\u2010\u03b3 and IL<\/jats:styled-content>\u201012 in cell culture was evaluated in relation to the presence of IFN<\/jats:styled-content>\u03b3<\/jats:italic> and IL<\/jats:styled-content>12<\/jats:italic> wild versus variant genotypes, respectively.<\/jats:p><\/jats:sec>Results<\/jats:title>The distributions of IFN<\/jats:styled-content>\u03b3<\/jats:italic> rs2430561<\/jats:ext-link>, IFN<\/jats:styled-content>\u03b3<\/jats:italic> rs35314021<\/jats:ext-link>, IL<\/jats:styled-content>12A<\/jats:italic> rs568408<\/jats:ext-link>, IL<\/jats:styled-content>12A<\/jats:italic> rs2243115<\/jats:ext-link> and IL<\/jats:styled-content>12B<\/jats:italic> rs3212227<\/jats:ext-link> SNP<\/jats:styled-content> did not differ between BCG<\/jats:styled-content> osteitis patients and Finnish population\u2010based controls. For IFN<\/jats:styled-content>\u03b3<\/jats:italic> rs2430561<\/jats:ext-link>, IFN<\/jats:styled-content>\u03b3<\/jats:italic> rs35314021<\/jats:ext-link> and IL<\/jats:styled-content>12A<\/jats:italic> rs2243115<\/jats:ext-link>, the negative result was confirmed by comparing the minor allele frequencies (MAF<\/jats:styled-content>) in BCG<\/jats:styled-content> osteitis cases with those in the publicly available genome aggregation database, including data for 3,472 Finnish persons. Instead, for IL<\/jats:styled-content>12A<\/jats:italic> rs568408<\/jats:ext-link> and IL<\/jats:styled-content>12B<\/jats:italic> rs3212227<\/jats:ext-link>, the comparison of MAF<\/jats:styled-content> in BCG<\/jats:styled-content> osteitis cases with those in population\u2010based and in aggregation\u2010based controls gave conflicting results. The presence of the wild versus variant genotype had no significant association with IL<\/jats:styled-content>\u201012 or IFN<\/jats:styled-content>\u2010\u03b3 production in BCG<\/jats:styled-content>\u2010stimulated cell cultures.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>IFN<\/jats:styled-content>\u03b3<\/jats:italic> gene polymorphisms did not show any association with BCG<\/jats:styled-content> osteitis after newborn vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13998","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T19:59:26Z","timestamp":1567108766000},"page":"982-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interferon\u2010\u03b3 and interleukin\u201012 production in relation to gene polymorphisms in bacillus Calmette\u2013Gu\u00e9rin osteitis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-1919","authenticated-orcid":false,"given":"Matti","family":"Korppi","sequence":"first","affiliation":[{"name":"Center for Child Health Research Faculty of Medicine and Biotechnology University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Ter\u00e4sj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Lauhkonen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Faculty of Medicine and Biotechnology University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"P\u00f6yh\u00f6nen","sequence":"additional","affiliation":[{"name":"Center for Child Health Research Faculty of Medicine and Biotechnology University of Tampere and University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-9449","authenticated-orcid":false,"given":"Kirsi","family":"Nuolivirta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sein\u00e4joki Central Hospital Sein\u00e4joki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiushui","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine University of Turku Turku Finland"},{"name":"Department of Medical Microbiology Capital Medical University Beijing 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