{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:25:32Z","timestamp":1773811532883,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The hypothesis of the Developmental Origins of Health and Disease states that environmental factors during fetal and infantile life are risk factors for some chronic diseases in adulthood. Few studies, however, have confirmed this hypothesis early in childhood. Therefore, we assessed how premature birth and low\u2010birthweight (<jats:styled-content style=\"fixed-case\">LBW<\/jats:styled-content>) affect the renal function of Japanese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study surveyed 168 patients who were born before 35\u00a0weeks of gestation and were cared for at the present neonatal intensive care unit. Follow\u2010up duration was &gt;2\u00a0years. Serum creatinine (<jats:styled-content style=\"fixed-case\">sC<\/jats:styled-content>r) and estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) recorded in medical records were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> at 2\u00a0years of age was significantly correlated with birthweight and gestational age (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Approximately 10.7% of the children had low <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> (&lt;90\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>) without clinical symptoms or abnormal urine examination. These children had high <jats:styled-content style=\"fixed-case\">sC<\/jats:styled-content>r on day 7 after birth (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) and delayed recovery of these levels during the first month after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Premature gestational age and <jats:styled-content style=\"fixed-case\">LBW<\/jats:styled-content> directly affect renal function in young children. High <jats:styled-content style=\"fixed-case\">sC<\/jats:styled-content>r on day 7 after birth is a risk factor for chronic kidney disease in children. Careful follow up of renal function is therefore required for premature infants and infants with <jats:styled-content style=\"fixed-case\">LBW<\/jats:styled-content> beginning in early childhood to prevent renal dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14004","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T06:33:46Z","timestamp":1567924426000},"page":"1244-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term renal follow up of preterm neonates born before 35\u00a0weeks of gestation"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-3986","authenticated-orcid":false,"given":"Akiyoshi","family":"Horie","sequence":"first","affiliation":[{"name":"Division of Pediatrics Shimane Prefectural Central Hospital Himebara, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Shimane Prefectural Central Hospital Himebara, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Koike","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Shimane Prefectural Central Hospital Himebara, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Hirade","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Shimane Prefectural Central Hospital Himebara, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Nariai","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Shimane Prefectural Central Hospital Himebara, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Neonatology Shimane Prefectural Central Hospital Himebara, Izumo, Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihide","family":"Katou","sequence":"additional","affiliation":[{"name":"Division of Neonatology Shimane Prefectural Central Hospital Himebara, Izumo, Shimane 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