{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:53:00Z","timestamp":1747187580889,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>I.v. atropine (IA<\/jats:styled-content>) for infantile hypertrophic pyloric stenosis (IHPS<\/jats:styled-content>) is a good alternative to pyloromyotomy but has not been broadly accepted. The lower success rate is one of the greatest disadvantages of IA<\/jats:styled-content>. We investigated the risk factors for unsuccessful results following IA<\/jats:styled-content> for IHPS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Medical records of patients with IHPS<\/jats:styled-content> who were admitted to Kimitsu Chuo Hospital between 2002 and 2016 and were initially given atropine sulfate were retrospectively reviewed. Atropine was given i.v. (0.1\u00a0mg\/kg\/day in eight divided doses). Oral feeding of milk was started with a small amount and increased in a stepwise fashion to full feed. IA<\/jats:styled-content> therapy was defined as unsuccessful in the presence of projectile vomiting more than three times a day or intolerance to a predetermined amount of milk.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 48 patients with IHPS<\/jats:styled-content>, 33 patients were successfully treated with IA<\/jats:styled-content> and 15 patients needed surgical intervention. On univariate analysis the risk factors for unsuccessful IA<\/jats:styled-content> therapy were younger age, lower bodyweight, and shorter duration of symptoms before diagnosis. On multivariate analysis age at diagnosis\u00a0<\u00a030\u00a0days was the only significant risk factor for unsuccessful IA<\/jats:styled-content> therapy (OR, 5.7\u00a0l P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.03).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Age at diagnosis\u00a0<\u00a030\u00a0days is a risk factor for unsuccessful IA<\/jats:styled-content> therapy in IHPS<\/jats:styled-content>. This might be considered when IA<\/jats:styled-content> therapy is used for neonates with IHPS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14009","type":"journal-article","created":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T12:24:11Z","timestamp":1568463851000},"page":"1151-1154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors for unsuccessful atropine therapy in hypertrophic pyloric stenosis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-6675","authenticated-orcid":false,"given":"Sachie","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Kimitsu Chuo Hospital Kisarazu City Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Takenouchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Kimitsu Chuo Hospital Kisarazu City Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-5179","authenticated-orcid":false,"given":"Keita","family":"Terui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medicine Chiba University Chiba City Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medicine Chiba University Chiba City Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Terui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Kimitsu Chuo Hospital Kisarazu City Chiba 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