{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:51:08Z","timestamp":1762145468640,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Group B <jats:italic>Streptococcus<\/jats:italic> (GBS) and <jats:italic>Escherichia coli<\/jats:italic> are leading causes of late\u2010onset sepsis (LOS) and bacterial meningitis in neonates and infants. This study aimed to describe clinical characteristics and outcomes of community\u2010acquired (CA) LOS caused by GBS and <jats:italic>E.\u00a0coli<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective observational study was performed in three university hospitals in Korea. All infants aged &lt;90\u00a0days who were diagnosed with GBS or <jats:italic>E\u00a0coli<\/jats:italic> CA\u2010LOS from 2011 to 2017 were enrolled. Data on the clinical characteristics and outcomes of GBS and <jats:italic>E.\u00a0coli<\/jats:italic> CA\u2010LOS were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty GBS and 43 <jats:italic>E.\u00a0coli<\/jats:italic> CA\u2010LOS cases were identified, which mostly (82\/83) included term or near\u2010term infants. Meningitis was identified in 54.1% of GBS CA\u2010LOS cases and in 30.3% of <jats:italic>E.\u00a0coli<\/jats:italic> CA\u2010LOS cases, and 88.4% of <jats:italic>E.\u00a0coli<\/jats:italic> CA\u2010LOS cases involved urosepsis. Ten percent each of GBS and non\u2010uropathogenic <jats:italic>E.\u00a0coli<\/jats:italic> (non\u2010UPEC) meningitis cases and all uropathogenic <jats:italic>E. coli<\/jats:italic> (UPEC) meningitis cases were diagnosed by pleocytosis without bacterial growth in the cerebrospinal fluid (CSF). Patients with non\u2010culture\u2010proven meningitis had lower CSF pleocytosis and protein levels and higher CSF\/serum glucose ratios than patients with culture\u2010proven meningitis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for all). One patient died of CA\u2010LOS, which was accompanied by meningitis with extended\u2010spectrum \u03b2\u2010lactamase\u2010producing non\u2010UPEC. Neurological complications developed in 22.5% of GBS CA\u2010LOS cases and in 2.3% of <jats:italic>E.\u00a0coli<\/jats:italic> CA\u2010LOS cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neurological complications were frequently observed in GBS CA\u2010LOS cases, although no mortality was observed. <jats:italic>Escherichia coli<\/jats:italic> CA\u2010LOS generally developed as urosepsis, which caused non\u2010culture\u2010proven meningitis and had a favorable outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14012","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T10:28:32Z","timestamp":1569580112000},"page":"1210-1215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical features and outcomes of community\u2010acquired late\u2010onset sepsis: Focusing on group B <i>Streptococcus<\/i> and <i>Escherichia coli<\/i>"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-6779","authenticated-orcid":false,"given":"Ki Wook","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Pediatrics Seoul National University Children\u2019s Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-0816","authenticated-orcid":false,"given":"Sun Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Children\u2019s Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungnam National University Hospital Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Pediatrics Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1097\/INF.0000000000000225"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1016\/j.jpeds.2018.05.048"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1186\/s12887-016-0618-6"},{"key":"e_1_2_8_5_1","first-page":"1280","volume-title":"Nelson Textbook of Pediatrics","author":"Nield 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