{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:53:02Z","timestamp":1747187582403,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["16K10093","17K10179","JP16K10092"],"award-info":[{"award-number":["16K10093","17K10179","JP16K10092"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17824886"],"award-info":[{"award-number":["17824886"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Premature infants have a high concentration of conjugated bilirubin in their blood, although they have a poor glucuronide conjugation of bilirubin. This may be due to developmental changes in the function of adenosine triphosphate binding cassette subfamily C member 2, which is involved in the cellular export of conjugated bilirubin. In the present study, we examined the developmental changes in the urinary coproporphyrin I\/(urinary coproporphyrin I+ urinary coproporphyrin III) ratio (UCP (I\/ [I + III])), a known biomarker for adenosine triphosphate binding cassette subfamily C member 2 function, in premature infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010one premature infants born between 25 and 32\u00a0weeks of gestation were included in the study. Urine samples were collected within 24\u00a0h of birth, and at 1\u00a0week and 3\u20134\u00a0weeks after birth. The samples were analyzed by high\u2010performance liquid chromatography to calculate UCP (I\/ [I + III]) to examine its association with postnatal age and corrected gestational age. Subjects were excluded if they had liver dysfunction, cholestasis, urinary tract infection, or chromosomal abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average UCP (I\/ [I + III]) within 24\u00a0h of birth, at 1\u00a0week, and at 3\u20134\u00a0weeks after birth was 0.84, 0.61, and 0.65, respectively. The UCP (I\/ [I + III]) within 24\u00a0h of birth was significantly higher than that measured at 1\u00a0week or 3\u20134\u00a0weeks after birth. There was no significant correlation between UCP (I\/ [I + III]) and the corrected gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The UCP (I\/ [I + III]) was higher within 24\u00a0h of birth. It decreased 1\u00a0week after birth and remained low without any significant changes for up to 4\u00a0weeks after birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14024","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T17:44:41Z","timestamp":1571507081000},"page":"65-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Developmental changes in urinary coproporphyrin ratio in premature infants"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-9390","authenticated-orcid":false,"given":"Yusei","family":"Nakata","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kochi Health Science Center Kochi\u2010City Kochi Japan"},{"name":"Department of Pediatrics Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-1839","authenticated-orcid":false,"given":"Takashi","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2016.01.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1960257"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198610000-00010"},{"key":"e_1_2_8_5_1","first-page":"37","volume-title":"Hepatobiliary, Splenic and Pancreatic Disease in Children: Medical and Surgical Management","author":"Onishi","year":"1997"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.08.110192.000435"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(89)80080-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/13.11.1006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/498757"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198406000-00017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197405000-00007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12965"},{"volume-title":"Manual of neonatal intensive care unit","year":"2014","author":"Japanese Neonatologist Association","key":"e_1_2_8_13_1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.09.047"},{"key":"e_1_2_8_15_1","first-page":"439","article-title":"Age\u2010dependent reference values of urinary porphyrins in children","volume":"34","author":"Minder EI","year":"1996","journal-title":"Eur. 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