{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T22:00:05Z","timestamp":1764194405903,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ibuprofen (IBU) has been used recently for the treatment of patent ductus arteriosus (PDA) in Japan. We aimed to investigate the efficacy and adverse events of IBU and compare them with those of indomethacin (IND) as PDA treatment for extremely low\u2010birthweight infants (ELBWIs), focusing on short\u2010term renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was conducted on 16 ELBWIs. The data from eligible patients were divided into two groups. Ten patients had undergone IND treatment (IND group) between January 2017 and June 2018, whereas six had undergone IBU treatment (IBU group) for PDA between July 2018 and December 2018. The IND group received 0.1\u00a0mg\/kg\/12h IND IV infusion for three doses, whereas the IBU group received 10\u00a0mg\/kg IV IBU infusion followed by 5\u00a0mg\/kg\/day for 2\u00a0days. We compared the efficacy for PDA closure and renal impairment between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in primary closure rates and the PDA ligation required were observed between the two groups. No significant differences were observed between the incidence of intraventricular hemorrhage and gastrointestinal complications in both groups. Changes in urine volume (%) in the IBU group were significantly higher than in the IND group at 24\u201336\u00a0h post\u2010administration. The urinary L\u2010type fatty acid binding protein concentration level at 7\u00a0days of life was significantly lower in the IBU group than in the IND group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although IBU was comparable to IND in PDA closure rate, IBU was superior to short\u2010term renal injury in ELBWIs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14057","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T14:59:16Z","timestamp":1574434756000},"page":"193-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The influence on renal function of ibuprofen treatment for patent ductus arteriosus in extremely low birthweight infants"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9471-6146","authenticated-orcid":false,"given":"Naoto","family":"Nishizaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akina","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Obinata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-0022","authenticated-orcid":false,"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.09.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-0903(03)00143-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12715"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1139\/y79-126"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.4.1672"},{"key":"e_1_2_8_9_1","first-page":"679","article-title":"Differential effects of ibuprofen and indomethacin in the regional circulation of the dog","volume":"219","author":"Feigen LP","year":"1981","journal-title":"J. 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