{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:31:25Z","timestamp":1768519885317,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ideal nutritive strategy for a neonate with congenital diaphragmatic hernia (CDH) has not been elucidated. The purpose of this study was to investigate the efficacy of early parenteral nutrition (PN) in CDH neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five CDH neonates admitted to a single hospital from January 2005 to December 2014 were retrospectively reviewed. For the first 4 years of the study period, neonates received non\u2010early PN (n\u2010EPN) (2005\u20132008, amino acids [AA] &lt;1.0\u00a0g\/kg\/day, no lipids administered). After the transitional period (TP) (2009\u20132011, AA 1.0\u20132.5\u00a0g\/kg\/day, lipid 1.0\u00a0g\/kg\/day), early PN (EPN) (2011\u20132014, AA \u22653.0\u00a0g\/kg\/day, lipid 1.0\u00a0g\/kg\/day) was performed. We investigated the clinical effect of PN for growth\u2010associated clinical variables and the outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The first day of AA administration was late in the n\u2010EPN period (6.0 \u00b1 4.6, 0.0 \u00b1 0.8, 0.1 \u00b1 0.3 ; n\u2010EPN, TP, EPN: in order). The final day of PN (11.0 \u00b1 3.7, 9.2 \u00b1 4.0, 12.4 \u00b1 3.9) and the first day of enteral feeding (4.5 \u00b1 1.9, 4.3 \u00b1 1.4, 4.5 \u00b1 3.2), the first day of full milk feeding (100 mL\/kg\/day) (10.8 \u00b1 5.4, 9.2 \u00b1 2.3, 11.5 \u00b1 3.5) were statistically equal in every period. The date and body weight at discharge showed no significant differences among the three groups, but the weight\u2010gain rate from birth to discharge was higher in the EPN group than in the n\u2010EPN group (<jats:italic>P <\/jats:italic>= 0.023). The rate of inhaled nitric oxide (NO) gas administration and the duration of ventilation showed no significant differences among the three groups. Severe PN\u2010associated liver disease was not noted during the observation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early PN for CDH neonates promotes weight gain in the neonatal intensive\u2010care unit. The long\u2010term efficacy and safety of EPN for CDH neonates should be elucidated by additional studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14083","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T04:52:53Z","timestamp":1575694373000},"page":"200-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early parenteral nutrition in neonates with congenital diaphragmatic hernia"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-3397","authenticated-orcid":false,"given":"Tomohide","family":"Yoshida","sequence":"first","affiliation":[{"name":"Maternity and Perinatal Care Center University of the Ryukyus Hospital Nishihara Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Goya","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center University of the Ryukyus Hospital Nishihara Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center University of the Ryukyus Hospital Nishihara Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Arakaki","sequence":"additional","affiliation":[{"name":"Department of Child Health and Welfare Graduate School of Medicine University of the Ryukyus Nishihara Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Sanabe","sequence":"additional","affiliation":[{"name":"Department of Digestive and General Surgery Graduate School of Medicine University of the Ryukyus Nishihara Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-9129","authenticated-orcid":false,"given":"Koichi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Child Health and Welfare Graduate School of Medicine University of the Ryukyus Nishihara Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.25746"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.09.037"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.20-9-e56"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444210"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211686"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211215"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2008.27.5.707"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36179-X"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.01.032"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.10.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000181841.07090.f4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001000"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31824e18a8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.204"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-2012-02750"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.36"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.042"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1139\/y01-042"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.74.2.F95"}],"container-title":["Pediatrics 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