{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:35:18Z","timestamp":1777318518966,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The World Health Organization has set a goal to eliminate mother\u2010to\u2010child transmission of syphilis to a target of &lt;50 cases per 100\u00a0000 live births. This study aimed to determine the rate of congenital syphilis and identify gaps in prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was conducted in a tertiary care center in Bangkok, Thailand. The study included all pregnant women with positive syphilis serology and their infants. All congenital syphilis cases were categorized according to Centers for Disease Control criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2013 to 2017, 69 syphilis\u2010infected pregnant women were included, with 30 congenital syphilis cases. The rate of congenital syphilis was 115 cases (95% CI 78\u2013164) per 100\u00a0000 live births. The median (interquartile range) maternal age was 21 (18\u201332)\u00a0years and 12 (17%) women had human immunodeficiency virus co\u2010infection. Regarding maternal treatment, 28 (41%) women had inadequate treatment due to 13 cases (19%) of late or no antenatal care, six cases (8%) of recent infection near delivery, five cases (7%) of failure of treatment provision, and four (6%) others. There were three syphilitic stillbirths who were prematurely born to untreated pregnant women and 67 live births (one set of twins) of which 27 met definitions of probable congenital syphilis. They received complete treatment with penicillin and had non\u2010reactive rapid plasma reagin within the first 6\u00a0months of life, with the exception of one who had non\u2010reactive rapid plasma reagin at the age of 7\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Congenital syphilis remains a problem in our setting. Nearly half of pregnant women who had syphilis had inadequate treatment. There is an urgent need to strengthen diagnosis and the treatment cascade of syphilis during antenatal care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14132","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T16:08:18Z","timestamp":1577722098000},"page":"330-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gaps in the elimination of congenital syphilis in a tertiary care center in Thailand"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-5537","authenticated-orcid":false,"given":"Suvaporn","family":"Anugulruengkitt","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Chulalongkorn Bangkok Thailand"},{"name":"Center of Excellence for Pediatric Infectious Diseases and Vaccines Chulalongkorn Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-1023","authenticated-orcid":false,"given":"Chatnapa","family":"Yodkitudomying","sequence":"additional","affiliation":[{"name":"Center of Excellence for Pediatric Infectious Diseases and Vaccines Chulalongkorn Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anongnart","family":"Sirisabya","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaninee","family":"Chitsinchayakul","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Watsamon","family":"Jantarabenjakul","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Chulalongkorn Bangkok Thailand"},{"name":"Center of Excellence for Pediatric Infectious Diseases and Vaccines Chulalongkorn Bangkok Thailand"},{"name":"Thai Red Cross Emerging Infectious Diseases Clinical Center King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surasith","family":"Chaithongwongwatthana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Obstetrics and Gynecology Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanyawee","family":"Puthanakit","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Faculty of Medicine Chulalongkorn Bangkok Thailand"},{"name":"Center of Excellence for Pediatric Infectious Diseases and Vaccines Chulalongkorn Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002329"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000909"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.16.185033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211720"},{"key":"e_1_2_8_6_1","volume-title":"Validation of Elimination of Mother\u2010to\u2010Child Transmission of HIV and Syphilis, Thailand 2013\u20132015 Report 2016","author":"Ministry of Public Health of Thailand"},{"key":"e_1_2_8_7_1","first-page":"66","article-title":"Elimination of congenital syphilis in Thailand: what can be done during antenatal period?","volume":"24","author":"Chayachinda C","year":"2016","journal-title":"Thai J. 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