{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:53:21Z","timestamp":1747187601099,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["JP21791030","JP26893013"],"award-info":[{"award-number":["JP21791030","JP26893013"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Arginine vasopressin (AVP) infusion has been shown to be a useful strategy for the management of systemic perfusion failure in premature infants. Our objective was to determine the characteristics of the blood flow redistribution induced by AVP infusion in premature fetal sheep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine sheep fetuses at 99 to 113\u00a0days of gestation were continuously infused with AVP. Measurement of blood flow to individual fetal organs was performed using a colored microsphere technique, with measurements performed at 30\u00a0min before and 90\u00a0min after the initiation of AVP infusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AVP infusion significantly increased blood flow to the medulla oblongata (<jats:italic>P <\/jats:italic>&lt; 0.05), and significantly decreased flow to the adrenal glands (from 492.0 \u00b1 239.6 to 364.9 \u00b1 143.3\u00a0mL\/min\/100\u00a0g, <jats:italic>P <\/jats:italic>&lt; 0.05) and heart (from 592.6 \u00b1 184.5 to 435.6 \u00b1 137.4\u00a0mL\/min\/100\u00a0g, <jats:italic>P <\/jats:italic>&lt; 0.05). The infusion significantly increased the vascular resistance in adrenal glands, kidneys, ileum, colon, heart, and cerebellum. In the brain, except for the cerebellum, no significant increase in resistance was identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no significant response to AVP infusion in cerebral blood flow in mid\u2010gestation fetal sheep. Our observations suggest that, under AVP stimulation, the blood flow to the adrenal glands and myocardium might be decreased due to an increase in vascular resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14141","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T12:50:53Z","timestamp":1578574253000},"page":"688-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organ blood flow in response to infusion of arginine vasopressin in premature fetal sheep"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-6355","authenticated-orcid":false,"given":"Shimpei","family":"Watanabe","sequence":"first","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takushi","family":"Hanita","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouta","family":"Koshinami","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Usuda","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"},{"name":"School of Women's and Infants' Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Center for Perinatal and Neonatal Medicine Tohoku University Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Kemp","sequence":"additional","affiliation":[{"name":"School of Women's and Infants' Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199608000-00024"},{"key":"e_1_2_8_3_1","first-page":"R1116","article-title":"Blood flow and oxygen delivery to fetal organs and tissues during sustained hypoxemia","volume":"258","author":"Rurak DW","year":"1990","journal-title":"Am. 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