{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:29:05Z","timestamp":1782602945591,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aplasia cutis congenita (ACC) is a rare congenital malformation characterized by a localized absence of skin. which most commonly affects the scalp. We performed the present study to elucidate the basic clinical data regarding ACC in Korea, including demographics, clinical features, radiological and therapeutic results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010nine patients (70 lesions) with ACC (35 from our department and 24 from a Koreamed database search) were enrolled. We assessed demographics, family and obstetrical histories, clinical features (multiplicity, subtype, size, shape, hair collar sign, location, and Frieden's classification), and radiologic and therapeutic results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients was 2.62\u00a0years, with a male\u2010to\u2010female ratio of 1.03. A minority of patients had a family history (three patients), birth trauma (one patient), maternal drug use (two patients), or human immunodeficiency virus infection (one patient) during pregnancy, and fetus papyraceus of placental infarcts (two patients). Six patients (6\/59, 10.17%) had multiple lesions. Scarring was the most common manifestation (39\/70, 55.71%). The scalp was the most commonly affected site (50 cases, 71.43%). Thirty\u2010nine patients (66.10%) met Frieden's type I classification (scalp ACC without multiple anomalies). Radiological investigations were performed in 30 patients (30\/59, 50.85%) with abnormal findings in eight patients. Twenty\u2010five patients (42.37%) were managed conservatively, and 17 patients (28.81%) were treated with local wound care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first and largest study assessing the basic clinical data of ACC in Korea. The results of the present study could be useful for pediatricians and dermatologists who routinely manage ACC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14192","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T07:49:22Z","timestamp":1581320962000},"page":"804-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Aplasia cutis congenita in Korea: Single center experience and literature review"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-8401","authenticated-orcid":false,"given":"Min\u2010Young","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology Pusan National University Hospital Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Lyong","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pusan National University Hospital Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pusan National University Hospital Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Chang","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pusan National University Yangsan Hospital Yangsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pusan National University Hospital Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u2010Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pusan National University Hospital Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-103155"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2016.07.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4264721"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002678"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2016.02.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442989"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310480"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2737"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002610"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/549825"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5385\/jksn.2011.18.2.359"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5468\/KJOG.2011.54.9.536"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.1.96"},{"key":"e_1_2_7_15_1","first-page":"463","article-title":"A case of Bart's syndrome","volume":"47","author":"Lee KY","year":"2009","journal-title":"Korean J. 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