{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:48:49Z","timestamp":1761709729856,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Toxic gliadin peptide damages enterocytes in celiac disease by causing oxidative stress. Thiols are organic compounds that defend against oxidative stress. This study aimed to investigate the changes in thiol\u2013disulfide homeostasis in children with celiac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included patients with celiac disease, children diagnosed with functional gastrointestinal disorders, and healthy children. Patients\u2019 serum\u00a0native and total thiol\u2013disulfide amounts, disulfide\/total thiol percentage ratios, disulfide \/ native thiol percentage ratios, and native thiol\/total thiol percentage ratios were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study involved 172 children, of whom 90 (52.3%) were girls. The mean participant age was 8.6 \u00b1 4.2\u00a0years. A total of 59 (34.3%) children had celiac disease, 56 (32.6%) had functional gastrointestinal disorders, and 57 (33.1%) were healthy. The total thiol and disulfide levels of patients with celiac disease (305 \u00b1 87\u00a0\u03bcmol\/L and 25 \u00b1 15\u00a0\u03bcmol\/L, respectively) were significantly lower than those of healthy children (349 \u00b1 82\u00a0\u03bcmol\/L and 40 \u00b1 15\u00a0\u03bcmol\/L, respectively) (<jats:italic>P <\/jats:italic>= 0.006 and <jats:italic>P &lt; <\/jats:italic>0.001, respectively). Native and total thiol levels (226 \u00b1 85\u00a0\u03bcmol\/L and 279 \u00b1 99\u00a0\u03bcmol\/L, respectively) in patients with celiac disease who consumed a gluten\u2010containing diet were significantly lower than those of patients who consumed a gluten\u2010free diet (278 \u00b1 64\u00a0\u03bcmol\/L and 327 \u00b1 69\u00a0\u03bcmol\/L, respectively) (<jats:italic>P <\/jats:italic>= 0.017 and <jats:italic>P <\/jats:italic>= 0.041, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thiol\u2013disulfide homeostasis, an important antioxidant defense component of the gastrointestinal system, is disrupted in children with celiac disease. A gluten\u2010free diet helped partially ameliorate this decline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14243","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T10:36:38Z","timestamp":1585823798000},"page":"950-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thiol\u2013disulfide homeostasis in children with celiac disease"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-9550","authenticated-orcid":false,"given":"Atakan","family":"Comba","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Training and Research Hospital Hitit University \u00c7orum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-5932","authenticated-orcid":false,"given":"Ay\u015fe Semra","family":"G\u00fcreser","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine Hitit University \u00c7orum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2696-381X","authenticated-orcid":false,"given":"Djursun","family":"Karasartova","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine Hitit University \u00c7orum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-562X","authenticated-orcid":false,"given":"Almila","family":"\u015eenat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara Y\u0131ld\u0131r\u0131m Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-3236","authenticated-orcid":false,"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara Y\u0131ld\u0131r\u0131m Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-3625","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"Taylan \u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine Hitit University \u00c7orum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283423f0a"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000128609"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0318-8"},{"key":"e_1_2_10_5_1","first-page":"1324820","article-title":"Oxidative and antioxidative status of children with celiac disease treated with a gluten free\u2010diet","volume":"2","author":"Rowicka G","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.06.009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4040243"},{"key":"e_1_2_10_8_1","first-page":"498","article-title":"Total oxidant status, total antioxidant capacity and ischemia modified albumin levels in children with celiac disease","volume":"57","author":"Sayar E","year":"2015","journal-title":"Turk. J. Pediatr."},{"key":"e_1_2_10_9_1","first-page":"498","article-title":"The relationship between severity of ulcerative colitis and thiol\u2010disulphide homeostasis","volume":"119","author":"Neselio\u011flu S","year":"2018","journal-title":"Bratisl. Lek. Listy."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.09.026"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"e_1_2_10_15_1","first-page":"285","article-title":"Free radicals and their role in different clinical conditions: an overview","volume":"1","author":"Sarma AD","year":"2010","journal-title":"Int. J. Pharma. Sci. Res."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.06.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2016.07.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0295"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.611509"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.3858"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v8.i2.120"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2333(02)00017-6"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1258\/000456307782268075"},{"key":"e_1_2_10_25_1","first-page":"452","article-title":"Plasma glutamine and cystine are decreased and negatively correlated with endomysial antibody in children with celiac disease","volume":"25","author":"Sevinc E","year":"2016","journal-title":"Asia. Pac. J. Clin. Nutr."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7552"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.14243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.14243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T19:39:55Z","timestamp":1708717195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.14243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/ped.14243"],"URL":"https:\/\/doi.org\/10.1111\/ped.14243","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"2019-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}