{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:53:34Z","timestamp":1747187614887,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Committee of Prion Disease and Slow Virus Infection"},{"name":"Research on Policy Planning and Evaluation for Rare and Intractable Diseases"},{"name":"Health and Labour Sciences Research Grants"},{"name":"The Ministry of Health, Labour and Welfare, Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Subacute sclerosing panencephalitis (SSPE) is a progressive neurologic disorder caused by the measles virus (MV) and is identified by positive MV\u2010specific antibody titers, detected mainly by hemagglutination inhibition (HI) tests in the cerebrospinal fluid (CSF). However, an alternative method, the enzyme immunoassay (EIA), has increasingly become a preferred method for detecting MV antibodies. To establish the index for SSPE diagnosis using EIA, we investigated the correlation between HI and EIA titers of MV antibodies in SSPE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on MV antibody titers and measurement methods at the time of diagnosis in 89 Japanese SSPE cases diagnosed between 1979 and 2006 were obtained by a survey. We also assessed the serum and CSF MV antibody titers in three patients with SSPE and serum MV antibody titers in 38 healthy adults using immunoglobulin G (IgG)\u2010EIA and HI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all cases diagnosed as SSPE, IgG\u2010EIA titers in the CSF were \u22650.49\u00a0IU\/mL. There was a positive correlation between serum antibody values in the controls measured by IgG\u2010EIA and HI. In patients with SSPE, both serum and CSF antibody values, measured by IgG\u2010EIA, and HI, were positively correlated, and a positive correlation was found between the serum and CSF MV antibody titers as measured by IgG\u2010EIA. The serum\/CSF MV antibody titer ratios determined by IgG\u2010EIA were &lt;20 in most SSPE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunoglobulin G\u2010EIA may be a suitable alternative method for SSPE diagnosis; however, its potential utility and the cut\u2010off point of \u22650.49\u00a0IU\/mL should be tested with additional patient cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14244","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T12:34:16Z","timestamp":1585830856000},"page":"920-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility of enzyme immunoassays for diagnosis of subacute sclerosing panencephalitis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-6577","authenticated-orcid":false,"given":"Hajime","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuto","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of 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