{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:57:33Z","timestamp":1775624253251,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased antimicrobial resistance is a problem in managing urinary tract infections (UTI). With this study we assessed the resistance patterns of urinary isolates in children with UTI between January 2017 and January 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted. Among 5,443 isolates, a total of 776 UTI episodes in 698 patients were included. Patients' gender, age, voiding dysfunction, UTI history, prophylaxis status, and presence of vesicoureteral reflux were noted. Patients were divided into three age groups: group 1 for ages \u226412\u00a0months; group 2 for ages 13\u201360\u00a0months; and group 3 for ages &gt;60\u00a0months. The susceptibilities of etiologic agents to different antimicrobials were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 54\u00a0months (range 1\u00a0month\u201321\u00a0years); male to female ratio was 1:5. The most common causative agent was <jats:italic>Escherichia coli<\/jats:italic> (83% of the cases), followed by <jats:italic>Klebsiella\u00a0pneumoniae<\/jats:italic> (7.5%). Resistance to ampicillin (62.6%) and co\u2010trimoxazole (39.8%) were remarkable in all isolates. Overall extended\u2010spectrum beta\u2010lactamase (ESBL) positivity was 23.5%. The highest resistance rates, higher ESBL positivity (28.6%), and <jats:italic>K.\u00a0pneumoniae<\/jats:italic> frequency (13.5%) were observed in group 1. Ceftriaxone resistance was significantly low (0.5%) in the ESBL (\u2212) group, which constituted the majority of the isolates. Higher resistance rates were observed among the patients on prophylaxis compared to those off prophylaxis (<jats:italic>P <\/jats:italic>&lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ceftriaxone can still be used for empirical treatment; however, initial urine culture results are crucial due to high ESBL positivity. Special consideration must be taken for patients under 1\u00a0year of age. Periodical surveillance studies are needed to explore the changing resistance patterns of uropathogens and modify treatment plans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14270","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T08:52:18Z","timestamp":1588150338000},"page":"1058-1063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The changing resistance patterns of bacterial uropathogens in children"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1451-4443","authenticated-orcid":false,"given":"Eda Didem","family":"Kurt\u2010\u015e\u00fck\u00fcr","sequence":"first","affiliation":[{"name":"Departments of Division of Nephrology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep Birsin","family":"\u00d6z\u00e7akar","sequence":"additional","affiliation":[{"name":"Departments of Division of Nephrology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Karaman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilg\u00fcn","family":"\u00c7akar","sequence":"additional","affiliation":[{"name":"Departments of Division of Nephrology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk","family":"G\u00fcriz","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-7470","authenticated-orcid":false,"given":"Fato\u015f","family":"Yal\u00e7\u0131nkaya","sequence":"additional","affiliation":[{"name":"Departments of Division of Nephrology Ankara University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.2.232"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organisation. 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