{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:42:37Z","timestamp":1774478557598,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to evaluate the presence of cardiac systolic and diastolic dysfunction in pediatric patients with steroid\u2010sensitive nephrotic syndrome (NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of 19 patients with debut\u2010relapse of NS aged 1\u201318\u00a0years and 30 sex and age\u2010matched healthy controls. Blood and urine samples, two M\u2010mode conventional echocardiograms and tissue Doppler velocity imaging were evaluated in both attack and remission periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With regard to conventional pulse wave Doppler (cPWD), steroid\u2010sensitive NS patients (both in debut \/ relapse and in remission periods) had a higher peak of late diastolic flow velocities (A peak), and patients in debut \/ relapse had a lower E\/A ratio than the control group, indicating diastolic dysfunction (overall <jats:italic>P<\/jats:italic> = 0.003 and <jats:italic>P<\/jats:italic> = 0.006, respectively). Based on tissue Doppler velocity imaging echocardiography results, patients in debut\/relapse had a higher A\u2032 and a lower E\u2032\/A\u2032 ratio (overall <jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> = 0.001, respectively). There was also a significant difference in the cPWD E\/TDI E\u2032 ratio between the patients showing an increased cPWD E\/TDI E\u2032 ratio in remission periods compared to in debut\/relapse periods (<jats:italic>P<\/jats:italic> = 0.09). The albumin levels were positively correlated with E\u2032\/A\u2032 and E\/ E\u2032 ratio (<jats:italic>r<\/jats:italic> = 0.609; <jats:italic>P<\/jats:italic> = 0.007, <jats:italic>r<\/jats:italic> = 0.472; <jats:italic>P<\/jats:italic> = 0.041 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systolic cardiac functions are preserved but diastolic functions are affected in steroid\u2010sensitive NS patients both in debut\/relapse and in remission periods in a relatively short time. The persistence of left ventricular (LV) dysfunction during the remission period requires special attention during the follow up for early detection of cardiac abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14285","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T11:25:18Z","timestamp":1588764318000},"page":"1364-1368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac functions in children with steroid\u2010sensitive nephrotic syndrome"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-9714","authenticated-orcid":false,"given":"Hulya","family":"Nalcacioglu","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Department Ondokuz Mayis University Faculty of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-1221","authenticated-orcid":false,"given":"Ozan","family":"Ozkaya","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Department Ondokuz Mayis University Faculty of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-0416","authenticated-orcid":false,"given":"Hasan Candas","family":"Kafali","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Department Ondokuz Mayis University Faculty of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-1354","authenticated-orcid":false,"given":"Demet","family":"Tekcan","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Department Ondokuz Mayis University Faculty of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6605-8553","authenticated-orcid":false,"given":"Kemal","family":"Baysal","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Department Ondokuz Mayis University Faculty of Medicine Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.23-7-237"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1681\/ASN.V85769","article-title":"Prognostic significance of the early course of minimal change nephrotic syndrome: Report of the International Study of Kidney Disease in Children","volume":"8","author":"Tarshish P","year":"1997","journal-title":"J. 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