{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:57:16Z","timestamp":1790906236003,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To study the effect of levetiracetam in treating Sydenham chorea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected the data of 140 patients diagnosed with Sydenham chorea in the pediatric neurology and pediatric cardiology outpatient clinics of Van Training and Research Hospital between January 2010 and December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 140 patients, 102 (70%) of whom were girls, with mean age of onset 11.8\u00a0\u00b1\u00a02.7\u00a0years. Symptomatic treatment was initiated in all patients at the time of diagnosis; this medication was changed during follow up in 15 patients. The most frequently prescribed drugs were haloperidol and sodium (Na) valproate, and the most frequently discontinued one was haloperidol, due to side effects. The second\u2010choice drug was most often levetiracetam. Clinical response often began within the first 2\u00a0weeks, with Na valproate (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), within 4\u00a0weeks with carbamazepine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037) but 1\u20136\u00a0months with haloperidol (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) and levetiracetam (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Time to full remission was similar with Na valproate, carbamazepine, haloperidol, and levetiracetam (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.276). Our study indicated that levetiracetam was as effective as the other commonly used drugs in the symptomatic treatment of Sydenham chorea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Levetiracetam might be an option in the treatment of Sydenham chorea because of its acceptable effect and safety profile. This observation needs further support with evidence obtained through controlled and blinded trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14318","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T10:29:19Z","timestamp":1590229759000},"page":"1264-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of levetiracetam in the treatment of Sydenham chorea"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-7981","authenticated-orcid":false,"given":"Meltem","family":"Direk","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology Faculty of Medicine Mersin University Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0189-0063","authenticated-orcid":false,"given":"Serdar","family":"Epcacan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Van Training and Research Hospital University of Health Sciences Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerrin","family":"Epcacan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Van Training and Research Hospital University of Health Sciences Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem Derici","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Medicine Mersin University Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cetin","family":"Okuyaz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Faculty of Medicine Mersin University Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S12977"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2009.11.015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm892"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500484757"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073516"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102592"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.376"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00177-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.7.1140"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000084"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.8.1261"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.11.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807302614"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2016.04.010"},{"key":"e_1_2_8_16_1","first-page":"706","article-title":"Sydenham\u2019s chorea: physical and psychological symptoms of St Vitus dance","volume":"91","author":"Swedo SE","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12786"},{"key":"e_1_2_8_18_1","first-page":"120","article-title":"Childhood acute rheumatic fever in Ankara, Turkey","volume":"47","author":"Ozer S","year":"2005","journal-title":"Turk. 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