{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:39:50Z","timestamp":1784720390298,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aims of this study were to evaluate the outcomes of patients with severe bronchiolitis who received preemptive high\u2010flow nasal cannula (HFNC) treatment according to the authors\u2019 protocol, and to identify potential baseline characteristics that might predict patients who will not benefit from HFNC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective chart review of patients with severe bronchiolitis, who received preemptive HFNC treatment according to the authors\u2019 protocol and who were admitted to the pediatric emergency department between January 1, 2015, and December 31, 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four patients in total were enrolled over the 2 year period. Twenty\u2010three patients (27.3%) failed HFNC. Of these, four responded to non\u2010invasive mechanical ventilation and 19 required subsequent invasive ventilation. According to logistic regression analysis, existence of a chronic condition, significant tachycardia, existence of dehydration, and a venous pH &lt;7.30 at admission were found to be predictors of HFNC failure. There were no cases of pneumothorax or any other reported adverse effects related to HFNC therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preemptive HFNC treatment, complying with a preestablished protocol, might be a safe way to support patients with severe bronchiolitis in high\u2010volume, resource\u2010limited pediatric emergency departments. The existence of a chronic condition, significant tachycardia, dehydration, and a venous pH &lt;7.30 at admission could be risk factors for preemptive HFNC treatment failure in severe bronchiolitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14325","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T11:45:06Z","timestamp":1590752706000},"page":"1339-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preemptive high\u2010flow nasal cannula treatment in severe bronchiolitis: Results from a high\u2010volume, resource\u2010limited pediatric emergency department"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1078-9781","authenticated-orcid":false,"given":"Fulya","family":"Kamit","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit Tepecik Teaching and Research Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Anil","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Tepecik Teaching and Research Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Berna","family":"Anil","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Tepecik Teaching and Research Hospital Izmir Katip Celebi University, Medical School Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Berksoy","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Tepecik Teaching and Research Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Gokalp","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Tepecik Teaching and Research Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2004.tb05993.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3877"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1589"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1201-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2014-0125"},{"key":"e_1_2_9_7_1","volume-title":"Acute respiratory failure in children under one year. 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