{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:20:27Z","timestamp":1768616427352,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1RO3HD077422\u201001A1"],"award-info":[{"award-number":["1RO3HD077422\u201001A1"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R44HD080412\u201005"],"award-info":[{"award-number":["R44HD080412\u201005"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Phototherapy is an effective treatment for neonatal jaundice. Treatment indication uses total serum bilirubin (TSB), although unbound bilirubin (Bf) more accurately predicts disability risk. The goals of this investigation were to examine the response of Bf and TSB to phototherapy in preterm infants, and we hypothesized that (i) TSB and Bf respond differently; (ii) the relationship between TSB and Bf is altered; and (iii) unexpected Bf elevations are found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and seventeen preterm infants &lt;2\u00a0kg at birth and receiving (IL) were enrolled; and measurements of TSB and Bf were obtained. TSB was measured by the diazo method and Bf with a fluorescent Bf sensor BL22P1B11\u2010Rh.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial mean (\u00b1 SD) TSB and Bf levels (41.4\u00a0\u00b1\u00a06.9\u00a0h) were 8.0\u00a0\u00b1\u00a09.0\u00a0mg\/dL and 16.9\u00a0\u00b1\u00a012.4\u00a0nmol\/L (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The rates of rise (ROR) were 0.21\u00a0\u00b1\u00a00.10\u00a0mg\/dL\/h for TSB and 0.38\u00a0\u00b1\u00a00.33\u00a0nmol\/L\/h for Bf. Phototherapy reduced TSB from 8.0\u00a0\u00b1\u00a09.0 to 5.8\u00a0\u00b1\u00a09.4\u00a0mg\/dL (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.068) but Bf did not change (16.9\u00a0\u00b1\u00a012.4 to 14.1\u00a0\u00b1\u00a09.4\u00a0nmol\/L <jats:italic>P<\/jats:italic>\u00a0=\u00a0n.s.). Bf levels were &gt;11\u00a0nmol\/L in 64, &gt;17\u00a0nmol\/L in 18, and &gt;22\u00a0nmol\/L in 7 infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bf and TSB responded differently. While TSB and Bf correlated well before phototherapy, they did not correlate during phototherapy. TSB showed a trend toward a reduction with treatment, Bf did not. While TSB ROR information is not helpful, ROR Bf data can be utilized to anticipate treatment. Potentially high Bf levels existed before and after phototherapy and the mean Bf level at phototherapy termination remained elevated in a significant proportion of infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14346","type":"journal-article","created":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T20:04:40Z","timestamp":1592165080000},"page":"1357-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unbound bilirubin levels in phototherapy\u2010treated preterm infants receiving soy\u2010based lipid emulsion"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-1043","authenticated-orcid":false,"given":"Thomas","family":"Hegyi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Robert Wood Johnson Medical School Rutgers, The State University of NJ New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Kleinfeld","sequence":"additional","affiliation":[{"name":"Fluoresprobe Sciences San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Huber","sequence":"additional","affiliation":[{"name":"Fluoresprobe Sciences San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Weinberger","sequence":"additional","affiliation":[{"name":"Division of Neonatal\u2010Perinatal Medicine Cohen Children\u2019s Medical Center Zucker School of Medicine at Hofstra\/Northwell New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naureen","family":"Memon","sequence":"additional","affiliation":[{"name":"MidAtlantic Neonatology Associates Morristown NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Carayannopoulos","sequence":"additional","affiliation":[{"name":"Pathology Robert Wood Johnson Medical School Rutgers, The State University of NJ New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Alpert Medical School of Brown University Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289503400207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000349995"},{"issue":"4","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1542\/peds.69.4.481","article-title":"Unbound bilirubin and kernicterus in low\u2010birth\u2010weight infants","volume":"69","author":"Cashore WJ","year":"1982","journal-title":"Pediatrics"},{"issue":"1","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1542\/peds.93.1.50","article-title":"Vigintiphobia, unbound bilirubin, and auditory brainstem responses","volume":"93","author":"Funato M","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.4.664"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.32967"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1646"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00152"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.07.063"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.121269"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(58)91849-X"},{"issue":"6","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1542\/peds.41.6.1047","article-title":"Prevention of hyperbilirubinemia of prematurity by phototherapy","volume":"41","author":"Lucey J","year":"1968","journal-title":"Pediatrics"},{"issue":"5","key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1542\/peds.92.5.651","article-title":"Neonatal hyperbilirubinemia and long\u2010term outcome: another look at the Collaborative Perinatal Project","volume":"92","author":"Newman TB","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30579-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110362529"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803024"},{"issue":"5","key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1542\/peds.68.5.738","article-title":"of Pediatrics. 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