{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:53:47Z","timestamp":1747187627039,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effectiveness of growth hormone (GH) treatment for height gain in short\u2010stature children born small for gestational age (SGA) with extremely low birthweight (ELBW; birthweight &lt;1,000\u00a0g) remains largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In study 1, 35 prepubertal Japanese children born SGA with ELBW were categorized into three groups based on the presence or absence of catch\u2010up growth by age 3 (CU(+) and CU(\u2212), respectively) and GH treatment (GH(+) and GH(\u2212), respectively). Height standard deviation (SD) scores (HT\u2010SDS) in the CU\u2212\/GH+ group (<jats:italic>n<\/jats:italic> = 19) were compared with those in the age\u2010matched CU+\/GH\u2212 (<jats:italic>n<\/jats:italic> = 9) and CU\u2212\/GH\u2010 groups (<jats:italic>n<\/jats:italic> = 7). In study 2, 66 prepubertal Japanese SGA children treated with GH were divided into three groups by birthweight: &lt;1,000\u00a0g (<jats:italic>n<\/jats:italic> = 19), 1,000\u20132,000\u00a0g (<jats:italic>n<\/jats:italic> = 20), and &gt;2,000\u00a0g (<jats:italic>n<\/jats:italic> = 27). Changes in HT\u2010SDS during the initial 3\u00a0years of GH treatment were compared among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In study 1, the mean HT\u2010SDS in the CU\u2212\/GH+ group (\u22121.15 SD) was similar to that in the CU+\/GH\u2010 group (\u22121.39 SD) but higher than that in the CU\u2212\/GH\u2212 group (\u22122.24 SD). In study 2, GH achieved a height gain of +1.62 SD in the ELBW group, which was similar to that in the other groups (1,000\u20132,000\u00a0g: +1.46 SD, &gt;2,000\u00a0g: +1.53 SD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Growth hormone treatment in short\u2010stature children born SGA with ELBW increased HT\u2010SDS, which was similar to that in SGA children born with a birthweight \u22651,000\u00a0g. These results indicate that GH treatment may be an effective approach to promote adequate growth recovery for short\u2010stature children born SGA with ELBW.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14363","type":"journal-article","created":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T19:04:22Z","timestamp":1593371062000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth hormone treatment for extremely low birthweight children born small for gestational age"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-3914","authenticated-orcid":false,"given":"Shinsuke","family":"Onuma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Ida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-4251","authenticated-orcid":false,"given":"Takatoshi","family":"Maeyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3005-4707","authenticated-orcid":false,"given":"Yuri","family":"Etani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology Osaka Women's and Children's Hospital Osaka Japan"},{"name":"Department of Bone and Mineral Research Research Institute Osaka Women's and Children's Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1203\/00006450-199508000-00022"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1016\/j.earlhumdev.2006.07.002"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1542\/peds.111.6.1253"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1210\/jc.2006-2017"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1210\/jc.2002-021172"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1203\/01.PDR.0000148716.71231.81"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1210\/jc.2002-021123"},{"key":"e_1_2_7_9_1","first-page":"275","article-title":"Recombinant human growth hormone in short children born small for gestational age German Study Group","volume":"10","author":"Butenandt O","year":"1997","journal-title":"J Pediatr. 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