{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:35:32Z","timestamp":1771468532880,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis (CF) causes malabsorption of nutrients that exacerbate pulmonary problems. Nutritional interventions can improve pulmonary functions. We aimed to evaluate the effects of nutritional intervention in CF patients with malnutrition, and to determine if\u00a0there is a correlation between nutritional status and pulmonary functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 143 CF patients (67 females) with a mean 2\u00a0year follow\u2010up time. Patients\u2019 sociodemographic data, presenting symptoms and history were recorded. Height\u2010for\u2010age, weight\u2010for\u2010age, weight\u2010for\u2010length\/height (WFL\/H), and body mass index (BMI) were calculated in all patients. Patients were grouped as well nourished, mild malnutrition, moderate malnutrition, and severe malnutrition. These four groups were compared in terms of pulmonary function test results, lung infections, and the hospitalization rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the patients with a WFL\/H or BMI <jats:italic>z<\/jats:italic>\u2010scores that decreased, the frequency of lung infection was 74.1% and the hospitalization rate was 40.7%, versus 34% and 12.3%, respectively among the patients with a WFL\/H or BMI <jats:italic>z<\/jats:italic>\u2010scores that increased. The difference was significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01, respectively). The difference in bacterial lung infections differed significantly between the four nutritional status groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). Patients in the well\u2010nourished group had significantly higher pulmonary function test scores than the other groups. The forced expiratory volume in the first second differed significantly between the patients with and without an increase in the WFL\/H or BMI <jats:italic>z<\/jats:italic>\u2010scores (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The appropriate nutritional intervention to pediatric CF patients with malnutrition, decrease the frequency of lung infections, and improve respiratory function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14417","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T21:16:34Z","timestamp":1596489394000},"page":"316-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effects of nutritional status and intervention on pulmonary functions in pediatric cystic fibrosis patients"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-8910","authenticated-orcid":false,"given":"Ayse Ayzit","family":"Kilinc","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-7256","authenticated-orcid":false,"given":"Omer Faruk","family":"Beser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gastroenterology Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010 Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-8027","authenticated-orcid":false,"given":"Ebru Pelin","family":"Ugur","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-1422","authenticated-orcid":false,"given":"Fugen Cullu","family":"Cokugras","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gastroenterology Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010 Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-3936","authenticated-orcid":false,"given":"Haluk","family":"Cokugras","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Cerrahpasa Faculty of Medicine \u0130stanbul University\u2010Cerrahpasa \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.596"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1984-0462\/;2018;36;1;00006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602039"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2223\/1261"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0339-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.588"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.107891"},{"key":"e_1_2_7_9_1","first-page":"253","article-title":"Relationship between nutritional status and pulmonary function in adult cystic fibrosis patients","volume":"6","author":"Gozdzik J","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00038503"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.4.580"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10127"},{"key":"e_1_2_7_13_1","volume-title":"Physical Status: The Use and Interpretation of Anthropometry","author":"World Health Organisation","year":"1995"},{"key":"e_1_2_7_14_1","first-page":"773","article-title":"The Gomez classification. Time for a change?","volume":"58","author":"Gueri M","year":"1980","journal-title":"Bull. World Health Organ."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616671861"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.004"},{"key":"e_1_2_7_17_1","volume-title":"World Health Organisation Guideline (2013): Updates on the Management of Severe Acute Malnutrition in Infants and Children","author":"World Health Organization","year":"2013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1768"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.588"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.152"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12214"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37562016000000319"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15092020"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1727-9"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199208000-00011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2008.12.002"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10010009"},{"key":"e_1_2_7_28_1","unstructured":"LeungDH NarkewiczM.Cystic Fibrosis: Hepatobiliary Disease.2019."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2014.43574"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/1984-0462\/;2019;37;4;00007"},{"key":"e_1_2_7_31_1","first-page":"65","article-title":"A cross\u2010sectional study of pulmonary and nutritional status of children with cystic fibrosis","volume":"41","author":"Wells AL","year":"1985","journal-title":"J. Food Nutr."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.1999.0080"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1079\/NRR19910007"},{"key":"e_1_2_7_34_1","first-page":"375","volume-title":"Textbook of Paediatric Nutrition","author":"Hopkins RL","year":"1993"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.044"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.051409"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.040"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.14417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14417","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.14417","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T18:01:04Z","timestamp":1693591264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.14417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/ped.14417"],"URL":"https:\/\/doi.org\/10.1111\/ped.14417","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"2020-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}