{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:04:08Z","timestamp":1754600648241,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2019FB089"],"award-info":[{"award-number":["2019FB089"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760032"],"award-info":[{"award-number":["81760032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332018130"],"award-info":[{"award-number":["3332018130"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thiopurine methyltransferase (<jats:italic>TPMT<\/jats:italic>) polymorphism is one of the causes of the toxicity of thiopurines, but this is rarely seen in Asian populations. Rather, the nucleoside diphosphate\u2010linked X\u2010component motif 15 (<jats:italic>NUDT15<\/jats:italic>) gene is frequently linked to mercaptopurine (MP) intolerance and myelotoxicity in children with acute lymphoblastic leukemia (ALL) in East Asians; however, little is known about the <jats:italic>NUDT15<\/jats:italic> polymorphism in healthy children, especially in ethnic minorities in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 162 cases of healthy children with Bai nationality were enrolled for <jats:italic>NUDT15<\/jats:italic> genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three coding variants were identified in the <jats:italic>NUDT15<\/jats:italic> gene including rs186364861, rs746071566 and rs116855232. Notably, the rs746071566 and rs116855232 in <jats:italic>NUDT15<\/jats:italic> showed much higher frequencies in healthy children with Bai nationality compared with healthy East Asian populations, suggesting a concentrated distribution of these variants in the Bai ethnic group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This finding reveals the genetic polymorphism of <jats:italic>NUDT15<\/jats:italic> in children with Chinese Bai nationality, providing a biological genetic background for the individualized therapy of thiopurines for children with Bai nationality in China.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14480","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T15:45:04Z","timestamp":1600962304000},"page":"790-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>NUDT15<\/i> polymorphism in healthy children with Bai nationality in Yunnan of China"],"prefix":"10.1111","volume":"63","author":[{"given":"Gangling","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China"},{"name":"Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rizhao People\u2019s Hospital Rizhao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqin","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingpei","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan Women and Children Medical Care Centre Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlian","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China"},{"name":"Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China"},{"name":"Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-512X","authenticated-orcid":false,"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China"},{"name":"Yunnan Key Laboratory of Children's Major Disease Research Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.069252"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.01.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70354-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70140-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200208000-00003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05917.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1142-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000564"},{"key":"e_1_2_8_10_1","first-page":"910","article-title":"Pharmacogenomics for leukemia treatment","volume":"57","author":"Tanaka Y","year":"2016","journal-title":"Rinsho Ketsueki."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181d6baf5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3060"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13796"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.4671"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13518"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.134775"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3508"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.12809\/hkmj154783"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.55"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.75"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26189"},{"key":"e_1_2_8_22_1","first-page":"950","article-title":"Susceptibility to 6\u2010mercaptopurine toxicity related with NUDT15 and ABCC4 variants in Japanese childhood acute lymphoblastic leukemia","volume":"58","author":"Tanaka Y","year":"2017","journal-title":"Rinsho Ketsueki."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-782383"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14532"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2017.12"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4398-2"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.187658"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.351"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.283"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0190-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-018-3732-3"},{"key":"e_1_2_8_32_1","first-page":"4285","article-title":"Homozygous mutation in NUDT15 in childhood acute lymphoblastic leukemia with increased susceptibility to mercaptopurine toxicity: A case report","volume":"17","author":"Cheng J","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13943"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00916"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13905"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0448-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.09.024"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14258"},{"key":"e_1_2_8_39_1","article-title":"Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants","author":"Wang DS","year":"2020","journal-title":"Pediatr Res"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2019-0177"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11060594"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2292"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.14480","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T14:35:36Z","timestamp":1693406136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.14480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/ped.14480"],"URL":"https:\/\/doi.org\/10.1111\/ped.14480","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2021,6,8]]},"assertion":[{"value":"2020-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}