{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:18:19Z","timestamp":1788545899720,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital lung malformations (CLM) are rare disorders and surgical intervention is the definitive treatment. Our aim is to evaluate the long\u2010term lung function of patients with CLM after surgery compared to healthy children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen children with CLM (M\/F: 9\/7) and 30 age\u2010matched, healthy controls (M\/F: 13\/17) were included in the study. Demographic data were recorded and both groups were compared by spirometry and the nitrogen\u2010based Lung Clearance Index (LCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean \u00b1 SD age of the patients was 12.0 \u00b1 5.4\u00a0years. The mean forced expiratory volume in 1\u00a0s (FEV<jats:sub>1<\/jats:sub>), forced vital capacity (FVC), FEV<jats:sub>1<\/jats:sub>\/FVC, and forced expiratory flow between 25% and 75% of force expiration (FEF<jats:sub>25\u201075<\/jats:sub>) predicted was, 86.68 \u00b1 16.65, 88.00 \u00b1 14.58, 97.44 \u00b1 9.89, and 79.00 \u00b1 26.41, respectively in the patient group. Patients with CLM had significantly lower values in FEV<jats:sub>1<\/jats:sub>, FVC, FEF<jats:sub>25\u201075<\/jats:sub> than healthy controls (<jats:italic>P<\/jats:italic> = 0.002, <jats:italic>P<\/jats:italic> 0.007, <jats:italic>P<\/jats:italic> 0.045). While the mean LCI<jats:sub>2,5%<\/jats:sub> value in patients' group was 8.33 \u00b1 1.52, it was 7.28 \u00b1 0.80 in healthy controls (<jats:italic>P =<\/jats:italic> 0.023). Strong inverse correlation between LCI and FEV<jats:sub>1<\/jats:sub>, FEV<jats:sub>1<\/jats:sub>\/FVC was detected in the patient group (<jats:italic>P<\/jats:italic> = 0.023; <jats:italic>r<\/jats:italic>: \u22120.581, <jats:italic>P<\/jats:italic> 0.017; <jats:italic>r<\/jats:italic>: \u22120.606 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed that, in long\u2010term follow\u2010up, patients who had surgery because of CLM have impairment in the pulmonary function compared to healthy children and LCI may be more accurate in detecting airway diseases early than spirometry.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14488","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T21:37:47Z","timestamp":1601415467000},"page":"704-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010term respiratory outcomes of post\u2010op congenital lung malformations"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-1297","authenticated-orcid":false,"given":"Alican","family":"Dincel","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Yilmaz Yegit","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almala Pinar","family":"Ergenekon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ela","family":"Erdem Eralp","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Gokdemir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gursu","family":"Kiyan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent","family":"Karadag","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology School of Medicine Marmara University Istanbul 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