{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:54:03Z","timestamp":1747187643115,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute tubulointerstitial nephritis (ATIN) is a rare cause of acute kidney injury in children that can lead to chronic kidney disease. The aim of this study was to describe the presenting features, etiology, and clinical characteristics of childhood ATIN, and to evaluate treatment modalities and renal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 38 patients who had been diagnosed with ATIN, were younger than 18\u00a0years old, and were admitted for at least 6 months of follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at diagnosis was 13.1\u00a0years (range 1.2\u201316.6\u00a0years). The female \/ male ratio was 1.37. The most common symptoms were abdominal pain (65.7%) and nausea \/ vomiting (55.2%). Twenty\u2010three of the patients had a history of drug intake (60.5%), and the most active drugs in the etiology were non\u2010steroidal anti\u2010inflammatory drugs (56.5%). Eleven patients were given steroid therapy due to severe kidney involvement and rapid increases in serum creatinine values, and ten of those patients were drug\u2010related ATIN cases. Other patients were given symptomatic treatment. Four patients needed several sessions of dialysis due to the severity of their acute renal failure. The follow\u2010up creatinine and estimated glomerular filtration rate levels were not statistically different between the symptomatic and corticosteroid treated groups (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although our study was unable to show the beneficial effect of corticosteroid therapy on the extent of renal recovery, the use of steroids may be preferable in severe nephritis because of the rapid recovery of estimated glomerular filtration rate with corticosteroid therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14495","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T02:53:05Z","timestamp":1601952785000},"page":"693-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics of childhood acute tubulointerstitial nephritis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-1565","authenticated-orcid":false,"given":"T\u00fclin","family":"G\u00fcng\u00f6r","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-6206","authenticated-orcid":false,"given":"Evrim Karg\u0131n","family":"\u00c7ak\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6483-8978","authenticated-orcid":false,"given":"Fatma","family":"Yaz\u0131l\u0131ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-4282","authenticated-orcid":false,"given":"Fehime Kara","family":"Ero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-4595","authenticated-orcid":false,"given":"Semanur","family":"\u00d6zdel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eda Didem","family":"Kurt\u2010Sukur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evra","family":"\u00c7elikkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Ba\u011flan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital Ankara 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